ZFIN ID: ZDB-GENE-980526-39
Gene Name: carbonic anhydrase
Gene Symbol: cahz    Nomenclature History

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Previous Names: cah, ca2b (1), cb588 (1), id:ibd5016 (1), wu:cegs2190, wu:fj65c09, zCA2-like b (1), zCAb (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits carbonate dehydratase activity. Involved in carbon dioxide transport and hypotonic salinity response. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; pleuroperitoneal region; and presumptive blood. Orthologous to several human genes including CA2 (carbonic anhydrase 2).
Genome Resources: Alliance (1),  Gene:30331 (1),  Ensembl(GRCz11):ENSDARG00000011166 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32934 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cahz N/A 1
    DISEASE ASSOCIATED WITH cahz HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive osteopetrosis 3 Alliance Osteopetrosis, autosomal recessive 3, with renal tubular acidosis 259730
    DISEASE ASSOCIATED WITH cahz VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hypotonic salinity response (more)
    Molecular Function carbonate dehydratase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018338 Carbonic anhydrase, alpha-class, conserved site
    Domain IPR001148 Alpha carbonic anhydrase domain
    Family IPR023561 Carbonic anhydrase, alpha-class
    Homologous_superfamily IPR036398 Alpha carbonic anhydrase domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cahz-201 (1)    Ensembl 1841
    ncRNA cahz-002 (1)    Ensembl 1627
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cahz No data available
    MARKER RELATIONSHIPS
    cahz Contained in: [BAC] CH211-121G18 (1)
    cahz Encodes: [EST] cb588 (1) (order this), cegs2190 (2) (order this), fj65c09 (1), ibd5016 (1)
    [cDNA] MGC:77128 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131110 (1) 1574 nt
    Genomic GenBank:BX927106 (1) 147604 nt
    Select Tool
    Polypeptide UniProtKB:Q92051 (1) 260 aa
    Sequence Information (all 15)
    ORTHOLOGY for cahz ( Chr: 2 )
    CITATIONS (57)