ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a
Previous Names: GDF6a (1), cb278 (1), darl, out, radar (1), rdr, sb:cb278
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 32 figures from 21 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  apical ectodermal ridge dorsal fin, apical ectodermal ridge median fin fold, apical ectodermal ridge pectoral fin bud, artery (all 66) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m233 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m306 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m390 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s327 Point Mutation Unknown Unknown ENU
  • Baier Lab
  • sa42788 Point Mutation Unknown Unknown ENU
    u768 Point Mutation Unknown Missense ENU
    u900 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-gdf6a (1), MO2-gdf6a, MO3-gdf6a (1), MO4-gdf6a (1), MO5-gdf6a (1)
    PHENOTYPE
    Data: 42 figures from 15 publications
    Observed in: apoptotic process, axial vasculature, blood circulation, blue sensitive photoreceptor cell (all 54) expand
    DISEASE ASSOCIATED WITH gdf6a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Klippel-Feil syndrome Klippel-Feil syndrome 1, autosomal dominant 118100
    Leber congenital amaurosis Leber congenital amaurosis 17 615360
    microphthalmia Microphthalmia, isolated 4 613094
    Microphthalmia with coloboma 6, digenic 613703
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gdf6a-001 (1) 2649
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM gdf6a
    Tg(-3.0gdf6a:GFP), Tg(gdf6a-ECR1:EGFP), Tg(gdf6a-ECR2:EGFP), Tg(gdf6a-ECR3:EGFP), Tg(gdf6a-ECR4:EGFP) (all 6) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gdf6aContained in: [BAC] CH211-69O18 (1) (order this), DKEY-99N20 (1) (order this)
    gdf6aContains: [STS] zfish37251-1545g02.p1c (1)
    gdf6aEncodes: [EST] cb278 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001159994 (1) 2630bp
    Genomic GenBank:CR925805 (1) 180576bp
    Select Tool
    Polypeptide RefSeq:NP_001153466 (1) 404aa
    Sequence Clusters UniGene:16432 (1)
    Sequence Information (all 12)
    OTHER gdf6a GENE PAGES
  • Gene:566470 (1)
  • VEGA:OTTDARG00000033504 (1)
  • Ensembl(GRCz10):ENSDARG00000053479 (1)
  • ORTHOLOGY for gdf6a (Chr: 16)
    Species Symbol Chromosome Accession # Evidence
    Human GDF6 8
  • Gene:392255
  • OMIM:601147
  • HGNC:4221
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Mouse Gdf6 4
  • MGI:95689
  • Gene:242316
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (69)