Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a
Previous Names: darl, GDF6a (1), rdr, cb278 (1), out, radar (1), sb:cb278
Nomenclature History
GENE EXPRESSION
All Expression Data: 30 figures from 19 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  apical ectodermal ridge dorsal fin, apical ectodermal ridge median fin fold, apical ectodermal ridge pectoral fin bud, artery (all 61) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 13 genotypes
Alleles: m233, m306, m390, r3, s327
Knockdown reagents: MO1-gdf6a (1), MO2-gdf6a, MO3-gdf6a (1), MO4-gdf6a (1), MO5-gdf6a (1)
PHENOTYPE
Data: 20 figures from 8 publications
Observed in: apoptotic process, axial vasculature, blood circulation, brain (all 33) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Klippel-Feil syndrome 1, autosomal dominant 118100
Leber congenital amaurosis 17 615360
Microphthalmia with coloboma 6, digenic 613703
Microphthalmia, isolated 4 613094
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of ventral identity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA gdf6a-001 (1) 2649
GENE PRODUCT DESCRIPTION No description available
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM gdf6a
Tg(-3.0gdf6a:GFP), Tg(gdf6a-ECR1:EGFP), Tg(gdf6a-ECR2:EGFP), Tg(gdf6a-ECR3:EGFP), Tg(gdf6a-ECR4:EGFP) (all 6) expand
SEGMENT (CLONE AND PROBE) RELATIONSHIPS
gdf6a Contained in: [BAC] CH211-69O18 (1) (order this)
gdf6a Contains: [STS] zfish37251-1545g02.p1c (1)
gdf6a Encodes: [EST] cb278 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001159994 (1) 2630 bp
Genomic GenBank:CR391914 (1) 170876 bp
Select Tool
Polypeptide RefSeq:NP_001153466 (1) 404 aa
Sequence Clusters UniGene:16432 (1)
Sequence Information (all 11)
OTHER gdf6a GENE PAGES
  • Gene:566470 (1)
  • VEGA:OTTDARG00000033504 (1)
  • Ensembl(Zv9):ENSDARG00000053479 (1)
  • MAPPING INFORMATION
    Chr: 16, 19 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish gdf6a 16, 19  
    Human GDF6 8 (8q22.1)
  • OMIM:601147
  • Gene:392255
  • Mouse Gdf6 4 ( 4.35 cM)
  • MGI:95689
  • Gene:242316
  • CITATIONS (60)