ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a    Nomenclature History

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Previous Names: GDF6a (1), bmp13a (1), cb278 (1), darl, out, radar (1), rdr, sb:cb278

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in several processes, including blood vessel development; camera-type eye development; and regulation of signal transduction. Is expressed in several structures, including blood vessel; digestive system; fin; immature eye; and nervous system. Used to study microphthalmia. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 17; bone disease (multiple); cleft lip; cleft palate; and isolated microphthalmia 4. Orthologous to human GDF6 (growth differentiation factor 6).
Genome Resources: Alliance (1),  Gene:566470 (1),  Ensembl(GRCz11):ENSDARG00000053479 (2)
GENE EXPRESSION
All Expression Data: 34 figures from 23 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m233 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m306 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m390 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s327 Point Mutation Unknown Premature Stop ENU
  • Baier Lab
  • sa42788 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • u768 Point Mutation Unknown Missense ENU
    u900 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gdf6a
    1
    MO1-gdf6a N/A 14
    MO2-gdf6a N/A 2
    MO3-gdf6a N/A 1
    MO4-gdf6a N/A 1
    MO5-gdf6a N/A 7
    DISEASE ASSOCIATED WITH gdf6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated microphthalmia 4 Alliance Microphthalmia, isolated 4 613094
    Klippel-Feil syndrome 1 Alliance Klippel-Feil syndrome 1, autosomal dominant 118100
    Leber congenital amaurosis 17 Alliance Leber congenital amaurosis 17 615360
    Microphthalmia with coloboma 6, digenic 613703
    Multiple synostoses syndrome 4 617898
    DISEASE ASSOCIATED WITH gdf6a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    microphthalmia gdf6as327/s327 standard conditions French et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process (more)
    Cellular Component extracellular space (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gdf6a-201 (1)    Ensembl 2649
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf6a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.0gdf6a:GFP) gdf6a GFP Danio rerio 3 3
    Tg(gdf6a-ECR1:EGFP) gdf6a EGFP Danio rerio 3 2
    Tg(gdf6a-ECR2:EGFP) gdf6a EGFP Danio rerio 3 2
    Tg(gdf6a-ECR3:EGFP) gdf6a EGFP Danio rerio 3 2
    Tg(gdf6a-ECR4:EGFP) gdf6a EGFP Danio rerio 3 2
    Tg(gdf6a-ECR5:EGFP) gdf6a EGFP Danio rerio 5 3
    MARKER RELATIONSHIPS
    gdf6a Contained in: [BAC] CH211-69O18 (1), DKEY-99N20 (1) (order this)
    gdf6a Contains: [STS] zfish37251-1545g02.p1c (1)
    gdf6a Encodes: [EST] cb278 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001159994 (1) 2630 nt
    Genomic GenBank:CR925805 (1) 180576 nt
    Select Tool
    Polypeptide UniProtKB:P85857 (1) 404 aa
    Sequence Information (all 12)
    ORTHOLOGY for gdf6a ( Chr: 16 )
    CITATIONS (84)