ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: GDF6a (1), bmp13a (1), cb278 (1), darl, out, radar (1), rdr, sb:cb278

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in several processes, including animal organ development, blood vessel morphogenesis, and neuron differentiation; used to study microphthalmia; orthologous to human GDF6 (growth  ...
GENE EXPRESSION
All Expression Data: 34 figures from 23 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m233 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m306 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m390 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s327 Point Mutation Unknown Premature Stop ENU
  • Baier Lab
  • sa42788 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • u768 Point Mutation Unknown Missense ENU
    u900 Point Mutation Unknown Premature Stop ENU
    Targeting reagents:
    PHENOTYPE
    Data: 55 figures from 20 publications
    Observed in:
    DISEASE ASSOCIATED WITH gdf6a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    isolated microphthalmia 4 Microphthalmia, isolated 4 613094
    Klippel-Feil syndrome Klippel-Feil syndrome 1, autosomal dominant 118100
    Leber congenital amaurosis 17 Leber congenital amaurosis 17 615360
    Multiple synostoses syndrome 4 617898
    Multiple synostoses syndrome 4 617898
    Microphthalmia with coloboma 6, digenic 613703
    DISEASE ASSOCIATED WITH gdf6a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    microphthalmia gdf6as327/s327 standard conditions French et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process (more)
    Cellular Component extracellular space (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gdf6a-201 (1) 2649
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM gdf6a
    MARKER RELATIONSHIPS
    gdf6aContained in: [BAC] CH211-69O18 (1) (order this), DKEY-99N20 (1) (order this)
    gdf6aContains: [STS] zfish37251-1545g02.p1c (1)
    gdf6aEncodes: [EST] cb278 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001159994 (1) 2630bp
    Genomic GenBank:CR925805 (1) 180576bp
    Select Tool
    Polypeptide UniProtKB:P85857 (1) 404aa
    Sequence Clusters UniGene:16432 (1)
    Sequence Information (all 13)
    OTHER gdf6a GENE PAGES
  • Alliance (1)
  • Gene:566470 (1)
  • VEGA:OTTDARG00000033504 (1)
  • Ensembl(GRCz11):ENSDARG00000053479 (2)
  • ORTHOLOGY for gdf6a (Chr: 16)
    CITATIONS (80)