Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a
Previous Names: darl, GDF6a (1), rdr, cb278 (1), out, radar (1), sb:cb278
Location: Chr: 16   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 31 figures from 20 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  apical ectodermal ridge dorsal fin, apical ectodermal ridge median fin fold, apical ectodermal ridge pectoral fin bud, artery (all 65) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 16 genotypes
Alleles: m233, m306, m390, r3, s327
Knockdown reagents: MO1-gdf6a (1), MO2-gdf6a, MO3-gdf6a (1), MO4-gdf6a (1), MO5-gdf6a (1)
PHENOTYPE
Data: 30 figures from 12 publications
Observed in: apoptotic process, axial vasculature, blood circulation, blue sensitive photoreceptor cell (all 40) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Klippel-Feil syndrome 1, autosomal dominant 118100
Leber congenital amaurosis 17 615360
Microphthalmia with coloboma 6, digenic 613703
Microphthalmia, isolated 4 613094
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of ventral identity (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA gdf6a-001 (1) 2649
GENE PRODUCT DESCRIPTION No description available
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM gdf6a
Tg(-3.0gdf6a:GFP), Tg(gdf6a-ECR1:EGFP), Tg(gdf6a-ECR2:EGFP), Tg(gdf6a-ECR3:EGFP), Tg(gdf6a-ECR4:EGFP) (all 6) expand
SEGMENT (CLONE AND PROBE) RELATIONSHIPS
gdf6a Contained in: [BAC] CH211-69O18 (1) (order this)
gdf6a Contains: [STS] zfish37251-1545g02.p1c (1)
gdf6a Encodes: [EST] cb278 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001159994 (1) 2630 bp
Genomic GenBank:CR391914 (1) 170876 bp
Select Tool
Polypeptide RefSeq:NP_001153466 (1) 404 aa
Sequence Clusters UniGene:16432 (1)
Sequence Information (all 11)
OTHER gdf6a GENE PAGES
  • Gene:566470 (1)
  • VEGA:OTTDARG00000033504 (1)
  • Ensembl(Zv9):ENSDARG00000053479 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish gdf6a 16  
    Human GDF6 8 (8q22.1)
  • OMIM:601147
  • Gene:392255
  • Mouse Gdf6 4 ( 4.35 cM)
  • MGI:95689
  • Gene:242316
  • Orthology Details
    CITATIONS (65)