ZFIN ID: ZDB-GENE-980526-373
Gene Name: growth differentiation factor 6a
Gene Symbol: gdf6a
Previous Names: GDF6a (1), cb278 (1), darl, out, radar (1), rdr, sb:cb278
Location: Chr: 16   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 32 figures from 21 publications
Directly Submitted Expression Data: 6 figures (30 images) from Thisse et al., 2001 [cb278]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  apical ectodermal ridge dorsal fin, apical ectodermal ridge median fin fold, apical ectodermal ridge pectoral fin bud, artery (all 66) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 18 Genotypes
Knockdown reagents: MO1-gdf6a (1), MO2-gdf6a, MO3-gdf6a (1), MO4-gdf6a (1), MO5-gdf6a (1)

Allele Type Mutagen Suppliers
m233 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m306 Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m390 Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s327 Point Mutation ENU
    PHENOTYPE
    Data: 35 figures from 13 publications
    Observed in: apoptotic process, axial vasculature, blood circulation, blue sensitive photoreceptor cell (all 46) expand
    DISEASE ASSOCIATED WITH gdf6a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Klippel-Feil syndrome Klippel-Feil syndrome 1, autosomal dominant 118100
    Leber congenital amaurosis Leber congenital amaurosis 17 615360
    microphthalmia Microphthalmia, isolated 4 613094
    Microphthalmia with coloboma 6, digenic 613703
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gdf6a-001 (1) 2649
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf6a
    Tg(-3.0gdf6a:GFP), Tg(gdf6a-ECR1:EGFP), Tg(gdf6a-ECR2:EGFP), Tg(gdf6a-ECR3:EGFP), Tg(gdf6a-ECR4:EGFP) (all 6) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gdf6a Contained in: [BAC] CH211-69O18 (1) (order this), DKEY-99N20 (1) (order this)
    gdf6a Contains: [STS] zfish37251-1545g02.p1c (1)
    gdf6a Encodes: [EST] cb278 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001159994 (1) 2630 bp
    Genomic GenBank:CR925805 (1) 180576 bp
    Select Tool
    Polypeptide RefSeq:NP_001153466 (1) 404 aa
    Sequence Clusters UniGene:16432 (1)
    Sequence Information (all 12)
    OTHER gdf6a GENE PAGES
  • Gene:566470 (1)
  • VEGA:OTTDARG00000033504 (1)
  • Ensembl(Zv9):ENSDARG00000053479 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish gdf6a 16  
    Human GDF6 8 (8q22.1)
  • OMIM:601147
  • Gene:392255
  • Mouse Gdf6 4 ( 4.35 cM)
  • MGI:95689
  • Gene:242316
  • Orthology Details
    CITATIONS (66)