Gene

her1

ID
ZDB-GENE-980526-125
Name
hairy-related 1
Symbol
her1 Nomenclature History
Previous Names
  • etID309753.5 (1)
  • Hes7 (1)
  • id:ibd5086
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Involved in negative regulation of transcription, DNA-templated and somite specification. Predicted to localize to nucleus. Is expressed in several structures, including germ ring; margin; mesoderm; presumptive mesoderm; and tail bud. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7).
Genome Resources
Note
None
Expression
All Expression Data
123 figures from 79 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Choorapoikayil et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With her1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 4, autosomal recessive 613686
Associated With her1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR032644 Transcription factor HES-7
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain Transcription factor HES-7
UniProtKB:Q9DF72 328
UniProtKB:Q90463 328
UniProtKB:A3KQ56 328
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations