ZFIN ID: ZDB-GENE-980526-125
Gene Name: hairy-related 1
Gene Symbol: her1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: etID309753.5 (1), Hes7 (1), id:ibd5086

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in negative regulation of transcription, DNA-templated and somite specification. Predicted to localize to nucleus. Is expressed in several structures, including germ ring; margin; mesoderm; presumptive mesoderm; and tail bud. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7).
Genome Resources: Alliance (1),  Gene:30287 (1),  Ensembl(GRCz11):ENSDARG00000014722 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2124 Point Mutation Exon 2 Premature Stop ENU
sa40604 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2173 Insertion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-her1 N/A 7
    MO2-her1 N/A 3
    MO3-her1 N/A 4
    MO4-her1 N/A 2
    MO5-her1 N/A 3
    MO6-her1 N/A 2
    TALEN1-her1 1
    DISEASE ASSOCIATED WITH her1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Alliance Spondylocostal dysostosis 4, autosomal recessive 613686
    DISEASE ASSOCIATED WITH her1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component transcription regulator complex (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA her1-201 (1)    Ensembl 1780
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM her1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.9her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg(her1:her1-Venus) her1 her1Venus Danio rerio 1 6
    Tg(her1:NLS-KikGR) her1 KikGRNLS Danio rerio 1 3
    tg(hes6-hsp70l:egfp-utr-her1) hes6hsp70l EGFPher1UTR Danio rerio 1 1
    Tg(hsp70l:her1,Xla.Eef1a1:GFP) hsp70l GFPher1 Danio rerioXenopus laevis 1 4
    Tg(hsp70l:Venus-her1) hsp70l her1Venus Danio rerio 1 1
    Tg1(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg2(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg3(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg4(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg5(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg6(-3.3her1:mCherry) her1 mCherry Danio rerio 1 2
    Tg7(-3.3her1:emGFP) her1 emGFP Danio rerio 1 3
    Tg8(-3.3her1:emGFP) her1 emGFP Danio rerio 1 2
    TgBAC(her1:d1EGFP) her1 d1EGFP Danio rerio 1 4
    TgBAC(her1:Venus) her1 Venus Danio rerio 1 4
    MARKER RELATIONSHIPS
    her1 Contained in: [BAC] CH211-283H6 (1)
    her1 Encodes: [EST] eu148 (1), ibd5086
    [cDNA] MGC:193878 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131078 (1) 1773 nt
    Genomic GenBank:BX537304 (1) 157564 nt
    Select Tool
    Polypeptide UniProtKB:A3KQ56 (1) 328 aa
    Sequence Information (all 15)
    ORTHOLOGY for her1 ( Chr: 5 )
    CITATIONS (179)