Gene

ndst1a

ID
ZDB-GENE-111012-2
Name
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
Symbol
ndst1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have [heparan sulfate]-glucosamine N-sulfotransferase activity and hydrolase activity. Involved in cranial skeletal system development. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in head; optic tectum; and pectoral fin. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Filipek-Górniok et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Filipek-Górniok et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ndst1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 46 Alliance Intellectual developmental disorder, autosomal recessive 46 616116
Associated With ndst1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000863 Sulfotransferase domain
Domain IPR021930 Heparan sulphate-N-deacetylase
Family IPR037359 Heparan sulfate sulfotransferase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Heparan sulfate sulfotransferase Heparan sulphate-N-deacetylase P-loop containing nucleoside triphosphate hydrolase Sulfotransferase domain
UniProtKB:E7F0G2 869
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations