Gene

gdnfb

ID
ZDB-GENE-110609-2
Name
glial cell derived neurotrophic factor b
Symbol
gdnfb Nomenclature History
Previous Names
  • si:ch73-311f13.2
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have growth factor activity. Predicted to be involved in negative regulation of neuron apoptotic process; peripheral nervous system development; and positive regulation of branching involved in ureteric bud morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gdnfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome 209880
pheochromocytoma Alliance {Pheochromocytoma, modifier of} 171300
{Hirschsprung disease, susceptibility to, 3} 613711
Associated With gdnfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR043401 Glial cell line-derived neurotrophic factor family
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Glial cell line-derived neurotrophic factor family Transforming growth factor-beta, C-terminal
UniProtKB:A0A0N4STS9 164
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations