ZFIN ID: ZDB-GENE-091020-11
Gene Name: cordon-bleu WH2 repeat protein
Gene Symbol: cobl    Nomenclature History

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Previous Names: im:7136115, si:ch211-207g17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have actin monomer binding activity. Involved in cilium assembly and embryonic organ morphogenesis. Predicted to localize to several cellular components, including cytoskeleton; cytosol; and ruffle. Is expressed in several structures, including Kupffer's vesicle; midbrain hindbrain boundary neural rod; nervous system; pronephros; and trunk. Orthologous to human COBL (cordon-bleu WH2 repeat protein).
Genome Resources: Alliance (1),  Gene:497312 (1),  Ensembl(GRCz11):ENSDARG00000091006 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019886Tg Transgenic Insertion Unknown Unknown DNA
la019887Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13808 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22756 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36044 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cobl N/A 1
    MO2-cobl N/A 1
    MO3-cobl N/A 1
    MO4-cobl N/A 1
    DISEASE ASSOCIATED WITH cobl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cobl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process auditory receptor cell stereocilium organization (more)
    Cellular Component cell projection (more)
    Molecular Function actin binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cobl-201 (1)    Ensembl 6230
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cobl polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cobl No data available
    MARKER RELATIONSHIPS
    cobl Contained in: [BAC] CH211-207G17
    cobl Encodes: [EST] IMAGE:7136115 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001289913 (1) 5448 nt
    Genomic GenBank:BX537113 (1) 218597 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QQ65 (1) 1369 aa
    Sequence Information (all 28)
    ORTHOLOGY for cobl ( Chr: 16 )
    CITATIONS (27)