Gene

tymp

ID
ZDB-GENE-100415-1
Name
thymidine phosphorylase
Symbol
tymp Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable 1,4-alpha-oligoglucan phosphorylase activity. Predicted to act upstream of or within pyrimidine nucleobase metabolic process. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tymp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitochondrial DNA depletion syndrome 1 Alliance Mitochondrial DNA depletion syndrome 1 (MNGIE type) 603041
Associated With tymp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017872 Pyrimidine-nucleoside phosphorylase, conserved site
Domain IPR000312 Glycosyl transferase, family 3
Domain IPR017459 Glycosyl transferase family 3, N-terminal domain
Family IPR000053 Thymidine/pyrimidine-nucleoside phosphorylase
Homologous_superfamily IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
Homologous_superfamily IPR036320 Glycosyl transferase family 3, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Glycosyl transferase, family 3 Glycosyl transferase family 3, N-terminal domain Glycosyl transferase family 3, N-terminal domain superfamily Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily Pyrimidine-nucleoside phosphorylase, conserved site Thymidine/pyrimidine-nucleoside phosphorylase
UniProtKB:A0A0G2L3Z2
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations