ZFIN ID: ZDB-GENE-091028-1
Gene Name: transforming growth factor, beta 1b
Gene Symbol: tgfb1b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have cytokine activity and type II transforming growth factor beta receptor binding activity. Involved in hematopoietic stem cell differentiation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; aphthous stomatitis; artery disease (multiple); bone disease (multiple); and lung disease (multiple). Is expressed in cardiovascular system; head; hematopoietic system; and pharynx. Orthologous to human TGFB1 (transforming growth factor beta 1).
Genome Resources: Alliance (1),  Gene:563884 (1),  Ensembl(GRCz11):ENSDARG00000034895 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3109 Point Mutation Unknown Premature Stop ENU
zf2126 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tgfb1b 1
CRISPR2-tgfb1b
2
CRISPR3-tgfb1b
2
MO1-tgfb1b N/A 1
MO2-tgfb1b N/A 1
DISEASE ASSOCIATED WITH tgfb1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Camurati-Engelmann disease Alliance Camurati-Engelmann disease 131300
cystic fibrosis Alliance {Cystic fibrosis lung disease, modifier of} 219700
Inflammatory bowel disease, immunodeficiency, and encephalopathy 618213
DISEASE ASSOCIATED WITH tgfb1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic progenitor cell differentiation (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Family IPR016319 Transforming growth factor-beta
Homologous_superfamily IPR029034 Cystine-knot cytokine
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tgfb1b-201 (1)    Ensembl 1403
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tgfb1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(tgfb1b:gfp) tgfb1b GFP Danio rerio 1 1
MARKER RELATIONSHIPS
tgfb1b Contained in: [BAC] CH211-51A20 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_687246 (1)
Genomic GenBank:AL929321 (1) 193470 nt
Select Tool
Polypeptide UniProtKB:E9QHW0 (1) 379 aa
Sequence Information (all 6)
ORTHOLOGY for tgfb1b ( Chr: 21 )
CITATIONS (32)