ZFIN ID: ZDB-GENE-090313-353
Gene Name: leiomodin 3 (fetal)
Gene Symbol: lmod3    Nomenclature History

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Previous Names: si:dkey-90a13.2, si:dkey-90a13.7 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have tropomyosin binding activity. Involved in muscle contraction and skeletal muscle thin filament assembly. Predicted to localize to striated muscle thin filament. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3).
Genome Resources: Alliance (1),  Gene:100149390 (1),  Ensembl(GRCz11):ENSDARG00000062662 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6731 Point Mutation Unknown Premature Stop ENU
sa6732 Point Mutation Unknown Splice Site ENU
sa13018 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lmod3
    1
    CRISPR2-lmod3
    1
    MO1-lmod3 N/A 1
    MO2-lmod3 N/A 1
    DISEASE ASSOCIATED WITH lmod3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nemaline myopathy 10 Alliance Nemaline myopathy 10 616165
    DISEASE ASSOCIATED WITH lmod3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle contraction (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin monomer binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lmod3-201 (1)    Ensembl 2260
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lmod3 polyclonal IgG Rabbit Proteintech
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lmod3 No data available
    MARKER RELATIONSHIPS
    lmod3 Contained in: [BAC] DKEY-90A13 (1) (order this), DKEY-193P22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_003201178 (1) 3190 nt
    Genomic GenBank:BX897727 (1) 236277 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7F7X0 (1) 670 aa
    Sequence Information (all 12)
    ORTHOLOGY for lmod3 ( Chr: 23 )
    CITATIONS (18)