ZFIN ID: ZDB-GENE-090313-273
Gene Name: solute carrier family 5 member 7a
Gene Symbol: slc5a7a    Nomenclature History

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Previous Names: hacta (1), high affinity choline transporter a (1), si:dkey-24h22.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have choline:sodium symporter activity. Predicted to be involved in acetylcholine biosynthetic process; chemical synaptic transmission; and choline transport. Predicted to localize to several cellular components, including axon; dendrite; and perikaryon. Is expressed in dorsal habenular nucleus. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 20 and distal hereditary motor neuronopathy type 7A. Orthologous to human SLC5A7 (solute carrier family 5 member 7).
Genome Resources: Alliance (1),  Gene:100005589 (1),  Ensembl(GRCz11):ENSDARG00000074860 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6594 Point Mutation Unknown Premature Stop ENU
sa38275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko638b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc5a7a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc5a7a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 20 Alliance Myasthenic syndrome, congenital, 20, presynaptic 617143
    distal hereditary motor neuronopathy type 7A Alliance Neuronopathy, distal hereditary motor, type VIIA 158580
    DISEASE ASSOCIATED WITH slc5a7a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process transmembrane transport (more)
    Cellular Component membrane (more)
    Molecular Function transmembrane transporter activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc5a7a-201 (1)    Ensembl 5150
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc5a7a No data available
    MARKER RELATIONSHIPS
    slc5a7a Contained in: [BAC] DKEY-24H22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001344561 (1)
    Genomic GenBank:BX901972 (1) 212798 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q620 (1) 592 aa
    Sequence Information (all 12)
    ORTHOLOGY for slc5a7a ( Chr: 1 )
    CITATIONS (16)