ZFIN ID: ZDB-GENE-130530-959
Gene Name: eyes shut homolog
Gene Symbol: eys    Nomenclature History

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Previous Names: si:ch211-69e5.1, zmp:0000000956

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including photoreceptor cell development; photoreceptor cell maintenance; and visual perception. Predicted to localize to several cellular components, including the cilium; cytoskeleton; and interphotoreceptor matrix. Used to study cone-rod dystrophy. Human ortholog(s) of this gene implicated in retinitis pigmentosa 25. Is expressed in eye photoreceptor cell; retina; and retinal rod cell. Orthologous to human EYS (eyes shut homolog).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000079519 (1),  Ensembl(GRCz11):ENSDARG00000106564 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hzu4 Small Deletion Exon 34 Frameshift TALEN
la018606Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rmc101 Small Deletion Exon 20 Frameshift, Premature Stop CRISPR
    sa9409 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9466 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9550 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17288 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22361 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31957 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35565 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35566 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42268 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sny10 Small Deletion Unknown Frameshift CRISPR
    sny13 Small Deletion Unknown Frameshift CRISPR
    sny14 Small Deletion Unknown Frameshift CRISPR
    sny593 Small Deletion Unknown Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-eys 1
    CRISPR2-eys 1
    CRISPR3-eys 1
    CRISPR4-eys 1
    TALEN1-eys 1
    DISEASE ASSOCIATED WITH eys HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 25 Alliance Retinitis pigmentosa 25 602772
    DISEASE ASSOCIATED WITH eys VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cone-rod dystrophy eyshzu4/hzu4 standard conditions Lu et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament organization (more)
    Cellular Component cell projection (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001791 Laminin G domain
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eys-201 (1)    Ensembl 700
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-eys polyclonal IgG Rabbit IHC Novus Biologicals, LLC
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eys No data available
    MARKER RELATIONSHIPS
    eys Contained in: [BAC] CH73-76L17 (1), CH211-69E5 (1), CH211-134J11 (1), DKEY-188I13 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:BX005106 (1) 216863 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B8JI71 (1) 2904 aa
    Sequence Information (all 4)
    ORTHOLOGY for eys ( Chr: 13 )
    CITATIONS (21)