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ZIRC
ZFIN ID: ZDB-GENE-080108-5
Gene Name: dedicator of cytokinesis 1
Gene Symbol: dock1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Involved in myelination in peripheral nervous system and myoblast fusion. Predicted to localize to the integral component of membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1).
Genome Resources: Alliance (1),  Gene:572187 (1),  Ensembl(GRCz11):ENSDARG00000099093 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22170 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28011 Point Mutation Unknown Premature Stop ENU
    sa31895 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl145 Point Mutation Unknown Unknown ENU
    stl365 Insertion Unknown Unknown TALEN
    stl366 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dock1 N/A 1
    MO2-dock1 N/A 1
    MO3-dock1 N/A 2
    MO4-dock1 N/A 2
    TALEN1-dock1 1
    TALEN2-dock1 1
    DISEASE ASSOCIATED WITH dock1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dock1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination in peripheral nervous system (more)
    Cellular Component integral component of membrane (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dock1-001 (1) 1143
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dock1 No data available
    MARKER RELATIONSHIPS
    dock1 Contained in: [BAC] CH211-232H12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001110011 (1) 5904 bp
    Genomic GenBank:CR848039 (1) 154190 bp
    Select Tool
    Polypeptide UniProtKB:A8E1V6 (1) 1866 aa
    Sequence Clusters UniGene:151687 (1)
    Sequence Information (all 43)
    ORTHOLOGY for dock1 ( Chr: 12 )
    CITATIONS (18)