Gene

htr2aa

ID
ZDB-GENE-070912-500
Name
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
Symbol
htr2aa Nomenclature History
Previous Names
  • htr2a
  • si:dkey-284e7.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have G protein-coupled serotonin receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and release of sequestered calcium ion into cytosol. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htr2aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alcohol dependence Alliance {Alcohol dependence, susceptibility to} 103780
endogenous depression Alliance {Major depressive disorder, response to citalopram therapy in} 608516
endogenous depression Alliance {Seasonal affective disorder, susceptibility to} 608516
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
{Anorexia nervosa, susceptibility to} 606788
{Obsessive-compulsive disorder, susceptibility to} 164230
Associated With htr2aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000455 5-Hydroxytryptamine 2A receptor
Family IPR002231 5-hydroxytryptamine receptor family
Domain Details Per Protein
Protein Length 5-Hydroxytryptamine 2A receptor 5-hydroxytryptamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:F1RCX7 402
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations