Gene

htr2aa

ID
ZDB-GENE-070912-500
Name
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
Symbol
htr2aa Nomenclature History
Previous Names
  • htr2a
  • si:dkey-284e7.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; release of sequestered calcium ion into cytosol; and response to drug. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htr2aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alcohol dependence Alliance {Alcohol dependence, susceptibility to} 103780
endogenous depression Alliance {Major depressive disorder, response to citalopram therapy in} 608516
endogenous depression Alliance {Seasonal affective disorder, susceptibility to} 608516
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
{Anorexia nervosa, susceptibility to} 606788
{Obsessive-compulsive disorder, susceptibility to} 164230
Associated With htr2aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000455 5-Hydroxytryptamine 2A receptor
Family IPR002231 5-hydroxytryptamine receptor family
Domain Details Per Protein
Protein Length 5-Hydroxytryptamine 2A receptor 5-hydroxytryptamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:F1RCX7 402
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations