ZFIN ID: ZDB-GENE-070912-301
Gene Name: potassium voltage-gated channel, KQT-like subfamily, member 3
Gene Symbol: kcnq3    Nomenclature History

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Previous Name: si:ch211-66b9.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have calmodulin binding activity and delayed rectifier potassium channel activity. Involved in chemical synaptic transmission. Predicted to localize to axon initial segment and voltage-gated potassium channel complex. Is expressed in central nervous system; heart; and inner ear. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3).
Genome Resources: Alliance (1),  Gene:799747 (1),  Ensembl(GRCz11):ENSDARG00000060085 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014976Tg Transgenic Insertion Unknown Unknown DNA
sa531 Point Mutation Unknown Premature Stop ENU
sa33002 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44545 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kcnq3 N/A 1
    MO2-kcnq3 N/A 1
    PHENOTYPE
    Data: Fig. 7 from Chege et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH kcnq3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    benign neonatal seizures Alliance Seizures, benign neonatal, 2 121201
    DISEASE ASSOCIATED WITH kcnq3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chemical synaptic transmission (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnq3-202 (1)    Ensembl 1186
    kcnq3-203 (1)    Ensembl 1354
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnq3 No data available
    MARKER RELATIONSHIPS
    kcnq3 Contained in: [BAC] CH211-66B9 (1)
    kcnq3 Encodes: [cDNA] MGC:171632 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110040 (1) 2580 nt
    Genomic GenBank:BX511268 (1) 167067 nt
    Select Tool
    Polypeptide UniProtKB:A7MBT2 (1) 401 aa
    Sequence Information (all 33)
    ORTHOLOGY for kcnq3 ( Chr: 2 )
    CITATIONS (23)