ZFIN ID: ZDB-GENE-060929-1178
Gene Name: forkhead box J1a
Gene Symbol: foxj1a    Nomenclature History

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Previous Names: foxj1 (1), id:ibd5134, zgc:153050

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including embryonic heart tube morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and regulation of cilium beat frequency involved in ciliary motility. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; nervous system; neural tube; renal system; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1).
Genome Resources: Alliance (1),  Gene:767737 (1),  Ensembl(GRCz11):ENSDARG00000101919 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nw3 Insertion Unknown Unknown CRISPR
sa2090 Point Mutation Unknown Premature Stop ENU
sq5717 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-foxj1a
1
CRISPR2-foxj1a
1
CRISPR3-foxj1a 1
CRISPR4-foxj1a 1
CRISPR5-foxj1a 1
MO1-foxj1a N/A 3
MO2-foxj1a N/A 4
MO3-foxj1a N/A 1
MO4-foxj1a N/A 1
MO5-foxj1a N/A 3
MO6-foxj1a N/A 3
DISEASE ASSOCIATED WITH foxj1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ciliary dyskinesia 43 Alliance Ciliary dyskinesia, primary, 43 618699
DISEASE ASSOCIATED WITH foxj1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium assembly (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-foxj1 monoclonal IgG1 Mouse IHC, WB Abcam plc
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM foxj1a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(foxj1a:EGFP) foxj1a EGFP Danio rerio 3 2
Tg(foxj1a:GFP) foxj1a GFP Danio rerio 2 8
tg(foxj1a:gfp,cryaa:gfp) cryaafoxj1a GFP Danio rerio 1 1
tg(foxj1a:icre,myl7:egfp) foxj1amyl7 CreEGFP Danio rerio 2 1
tg(foxj1a:mmu.arl13b-gfp,cryaa:gfp) cryaafoxj1a GFP Danio rerioMus musculus 1 1
Tg(foxj1a:ptk7a,cryaa:EGFP) cryaafoxj1a EGFPptk7a Danio rerio 4 2
Tg(hsp70l:foxj1a) hsp70l foxj1a Danio rerio 1 4
tg(xla.cryg:loxp-egfp,foxj1a:ptk7a-loxp-mcherry) foxj1a EGFPLOXPmCherryptk7a Danio rerioXenopus laevis 2 1
tg2(foxj1a:gfp) foxj1a GFP Danio rerio 1 1
MARKER RELATIONSHIPS
foxj1a Encodes: [EST] ibd5134 (1)
[cDNA] MGC:153050 (1), MGC:191713 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001076706 (1) 3786 nt
Genomic GenBank:CABZ01077367 (1) 32294 nt
Select Tool
Polypeptide UniProtKB:F1QDF8 (1) 458 aa
Sequence Information (all 20)
ORTHOLOGY for foxj1a ( Chr: 3 )
CITATIONS (75)