Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-060824-5
Gene Name: protein C (inactivator of coagulation factors Va and VIIIa), a
Gene Symbol: proca
Previous Names: proc, procl (1), si:ch1073-188c16.3, zgc:63987 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (5 images) from Thisse et al., 2004 [MGC:63987]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 4 genotypes
Alleles: hu3567, sa43
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Thrombophilia due to protein C deficiency, autosomal dominant 176860
Thrombophilia due to protein C deficiency, autosomal recessive 612304
GENE ONTOLOGY
Ontology GO Term
Biological Process blood coagulation (more)
Cellular Component extracellular region (more)
Molecular Function calcium ion binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000294 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001254 (1)
  • InterPro:IPR001314 (1)
  • InterPro:IPR009003 (1)
  • InterPro:IPR012224 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR017857 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR018114 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00011 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS00134 (1)
  • PROSITE:PS00135 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50240 (1)
  • PROSITE:PS50998 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00089 (1)
  • Pfam:PF00594 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000039704 (1) 1728
    ncRNA ottdart00000039705 (1) 870
    mRNA proc-001 (1) 2429
    ncRNA proc-002 (1) 552
    proc-003 (1) 554
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM proca No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    proca Contained in: [BAC] CH211-170H3 (1) (order this)
    [Fosmid] CH1073-188C16 (1) (order this)
    proca Encodes: [cDNA] MGC:63987 (1) (order this), MGC:174535 (1) (order this), MGC:193086 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200356 (1) 1680 bp
    Genomic GenBank:CU467941 (1) 133979 bp
    Select Tool
    Polypeptide UniProtKB:A8KC28 (1) 434 aa
    Sequence Clusters UniGene:85899 (1)
    Sequence Information (all 21)
    OTHER proca GENE PAGES
  • Gene:393327 (1)
  • VEGA:OTTDARG00000028988 (1)
  • VEGA:OTTDARG00000028991 (1)
  • Ensembl(Zv9):ENSDARG00000038258 (1)
  • MAPPING INFORMATION
    Chr: 2 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish proca 2  
    Human PROC 2 (2q13-q14)
  • OMIM:612283
  • Gene:5624
  • Mouse Proc 18 ( 17.94 cM)
  • MGI:97771
  • Gene:19123
  • CITATIONS (19)