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ZIRC
ZFIN ID: ZDB-GENE-060526-121
Gene Name: NIPBL cohesin loading factor a
Gene Symbol: nipbla    Nomenclature History

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Previous Names: si:ch211-234b6.2 (1), si:ch73-311f13.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; embryonic morphogenesis; and transcriptional activation by promoter-enhancer looping. Predicted to localize to the Scc2-Scc4 cohesin loading complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is expressed in Kupffer's vesicle; blastoderm; blastodisc; head; and lateral plate mesoderm. Orthologous to human NIPBL (NIPBL cohesin loading factor).
Genome Resources: Alliance (1),  Gene:570900 (1),  Ensembl(GRCz11):ENSDARG00000098272 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb274 Small Deletion Exon 3 Unknown CRISPR
ihb275 Indel Unknown Unknown CRISPR
ihb276 Insertion Exon 16 Unknown CRISPR
ihb277 Indel Exon 16 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa1954 Point Mutation Unknown Splice Site ENU
    sa8770 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nipbla 1
    CRISPR2-nipbla 1
    MO1-nipbla N/A 4
    MO2-nipbla N/A 2
    DISEASE ASSOCIATED WITH nipbla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cornelia de Lange syndrome 1 Alliance Cornelia de Lange syndrome 1 122470
    DISEASE ASSOCIATED WITH nipbla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive tract development (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nipbla-201 (1)    Ensembl 8317
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nipbla Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nipbla No data available
    MARKER RELATIONSHIPS
    nipbla Contained in: [BAC] CH73-74D12 (1) (order this), CH73-311F13 (1) (order this), CH211-234B6 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001246284 (1)
    Genomic GenBank:BX510907 (1) 154591 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IGM2 (1) 2382 aa
    Sequence Clusters UniGene:88335 (1)
    Sequence Information (all 15)
    ORTHOLOGY for nipbla ( Chr: 5 )
    CITATIONS (24)