Gene

tbk1

ID
ZDB-GENE-060512-359
Name
TANK-binding kinase 1
Symbol
tbk1 Nomenclature History
Previous Names
  • wu:fk70c05
  • zgc:136548 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in FTDALS4 and brain disease. Orthologous to human TBK1 (TANK binding kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from GarcĂ­a-Valtanen et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
frontotemporal dementia and/or amyotrophic lateral sclerosis-4 Alliance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 616439
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8} 617900
Associated With tbk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR041087 TANK binding kinase 1, ubiquitin-like domain
Domain IPR041309 TANK-binding kinase 1, coiled-coil domain 1
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily TANK-binding kinase 1, coiled-coil domain 1 TANK binding kinase 1, ubiquitin-like domain
UniProtKB:Q0GKD6 727
UniProtKB:A0A2H4DYR3 130
UniProtKB:A0A2H4DYP4 623
UniProtKB:Q1JPV3 365
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations