ZFIN ID: ZDB-GENE-060503-719
Gene Name: grainyhead-like transcription factor 2b
Gene Symbol: grhl2b
Sequence Ontology ID : SO:0000704

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Previous Names: grhl2, si:dkey-21k18.2

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(Including Attributions)
Location: Chr: 19 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
  anterior axial hypoblast, anterior neural plate, anterior neural rod, midbrain hindbrain boundary neural rod ventral region (all 19) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36799 Point Mutation Unknown Splice Site ENU
tsu086Gt Transgenic Insertion Unknown Unknown DNA
  • China Zebrafish Resource Center (CZRC) (order this)
  • Targeting reagents: CRISPR1-grhl2b (2), CRISPR2-grhl2b (1), CRISPR3-grhl2b (2), MO1-grhl2b (1), MO2-grhl2b (1) (all 6) expand
    PHENOTYPE
    Data: 5 figures from Dworkin et al., 2012
    Observed in: brain, hindbrain, midbrain, midbrain hindbrain boundary (all 8) expand
    DISEASE ASSOCIATED WITH grhl2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 28 Deafness, autosomal dominant 28 608641
    Ectodermal dysplasia/short stature syndrome 616029
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process involved in morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function transcription regulatory region DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007604 (1)
  • Pfam:PF04516 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA grhl2b-001 (1) 3699
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM grhl2b
    Tg(hsp70l:grhl2b-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    grhl2bContained in: [BAC] DKEY-21K18 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083072 (1) 1786bp
    Genomic GenBank:BX294657 (1) 124224bp
    Select Tool
    Polypeptide UniProtKB:F7VJQ5 (1) 601aa
    Sequence Clusters UniGene:119348 (1)
    Sequence Information (all 12)
    OTHER grhl2b GENE PAGES
  • Gene:100034503 (1)
  • VEGA:OTTDARG00000015777 (1)
  • Ensembl(GRCz10):ENSDARG00000061974 (1)
  • ORTHOLOGY for grhl2b (Chr: 19)
    CITATIONS (18)