ZFIN ID: ZDB-GENE-060503-719
Gene Name: grainyhead-like transcription factor 2b
Gene Symbol: grhl2b    Nomenclature History

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Previous Names: grhl2, si:dkey-21k18.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits transcription regulatory region DNA binding activity. Involved in apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to localize to nucleus. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Orthologous to human GRHL2 (grainyhead like transcription factor 2).
Genome Resources: Alliance (1),  Gene:100034503 (1),  Ensembl(GRCz11):ENSDARG00000061974 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36799 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tsu086Gt Transgenic Insertion Unknown Unknown DNA
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grhl2b
    2
    CRISPR2-grhl2b
    1
    CRISPR3-grhl2b
    2
    MO1-grhl2b N/A 1
    MO2-grhl2b N/A 2
    MO3-grhl2b N/A 2
    DISEASE ASSOCIATED WITH grhl2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 28 Alliance Deafness, autosomal dominant 28 608641
    Corneal dystrophy, posterior polymorphous, 4 618031
    Ectodermal dysplasia/short stature syndrome 616029
    DISEASE ASSOCIATED WITH grhl2b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    autosomal dominant nonsyndromic deafness grhl2btsu086Gt/tsu086Gt(AB) standard conditions Han et al., 2011
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process involved in morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function transcription regulatory region sequence-specific DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grhl2b-201 (1)    Ensembl 3699
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grhl2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:grhl2b-EGFP) hsp70l EGFPgrhl2b Danio rerio 1 3
    MARKER RELATIONSHIPS
    grhl2b Contained in: [BAC] DKEY-21K18 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083072 (1) 1786 nt
    Genomic GenBank:BX294657 (1) 124224 nt
    Select Tool
    Polypeptide UniProtKB:F7VJQ5 (1) 601 aa
    Sequence Information (all 11)
    ORTHOLOGY for grhl2b ( Chr: 19 )
    CITATIONS (27)