Gene

icam3

ID
ZDB-GENE-060503-219
Name
intercellular adhesion molecule 3
Symbol
icam3 Nomenclature History
Previous Names
  • si:ch211-233g21.1 (1)
  • si:ch211-74m13.3
  • vcap1x1 (1)
  • vcap1x2 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Acts upstream of or within cardiac muscle contraction and ventricular cardiac muscle cell development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in cardiovascular system. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; inflammatory bowel disease (multiple); liver cirrhosis; and uveitis (multiple). Orthologous to several human genes including ICAM1 (intercellular adhesion molecule 1); ICAM2 (intercellular adhesion molecule 2); and ICAM3 (intercellular adhesion molecule 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Hsieh et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Hsieh et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With icam3 Human Ortholog
No data available
Associated With icam3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin subtype
Domain IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013768 Intercellular adhesion molecule, N-terminal
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Intercellular adhesion molecule, N-terminal Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
UniProtKB:B8JHX2 360
UniProtKB:F1R8F2 318
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations