ZFIN ID: ZDB-GENE-060312-33
Gene Name: component of oligomeric golgi complex 4
Gene Symbol: cog4    Nomenclature History

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Previous Name: zgc:136860

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in proteoglycan metabolic process and skeletal system development. Predicted to localize to Golgi transport complex. Is expressed in nervous system; otic epithelium; otic vesicle protrusion; and pharyngeal arch cartilage. Used to study Saul-Wilson syndrome. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4).
Genome Resources: Alliance (1),  Gene:569049 (1),  Ensembl(GRCz11):ENSDARG00000054264 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1311 Small Deletion Unknown Unknown CRISPR
b1312 Small Deletion Unknown Unknown CRISPR
sa44664 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cog4 1
    CRISPR2-cog4 1
    DISEASE ASSOCIATED WITH cog4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation type IIj Alliance Congenital disorder of glycosylation, type IIj 613489
    Saul-Wilson syndrome Alliance Saul-Wilson syndrome 618150
    DISEASE ASSOCIATED WITH cog4 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Saul-Wilson syndrome cog4b1312/b1312 standard conditions Ferreira et al., 2018
    cog4b1311/b1311 standard conditions Ferreira et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteoglycan metabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function molecular_function (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cog4-201 (1)    Ensembl 3936
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cog4 No data available
    MARKER RELATIONSHIPS
    cog4 Contained in: [BAC] DKEY-97H16 (1) (order this), DKEYP-109H3 (1)
    cog4 Encodes: [cDNA] MGC:136860 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039823 (1) 2519 nt
    Genomic GenBank:CR376738 (1) 118757 nt
    Select Tool
    Polypeptide UniProtKB:Q29RB1 (1) 781 aa
    Sequence Information (all 11)
    ORTHOLOGY for cog4 ( Chr: 7 )
    CITATIONS (22)