ZFIN ID: ZDB-GENE-051127-39
Gene Name: actinin, alpha 2b
Gene Symbol: actn2b
Previous Names: actn2, wu:fd44c03, zgc:123223
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adaxial cell, cerebellum, diencephalon, eye (all 25) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Targeting reagents: MO1-actn2b (1), MO2-actn2b (1), MO3-actn2b (1), MO4-actn2b (1), MO5-actn2b (1)
PHENOTYPE
Data: 11 figures from 2 publications
Observed in: atrium, cardiac muscle myofibril, cardiac muscle cell sarcomere, cardiac muscle cell Z disc (all 24) expand
DISEASE ASSOCIATED WITH actn2b HUMAN ORTHOLOG 
Disease Ontology Term OMIM Term OMIM Phenotype ID
dilated cardiomyopathy Cardiomyopathy, dilated, 1AA, with or without LVNC 612158
Cardiomyopathy, hypertrophic, 23, with or without LVNC 612158
GENE ONTOLOGY 
Ontology GO Term
Biological Process eye development (more)
Molecular Function actin binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001589 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR002017 (1)
  • InterPro:IPR002048 (1)
  • InterPro:IPR011992 (1)
  • InterPro:IPR014837 (1)
  • InterPro:IPR018159 (1)
  • PROSITE:PS00019 (1)
  • PROSITE:PS00020 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50222 (1)
  • Pfam:PF00307 (1)
  • Pfam:PF00435 (1)
  • Pfam:PF08726 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA actn2b-001 (1) 2986
    aberrant processed transcript actn2b-002 (1) 2470
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-actn2 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM actn2b
    Tg(ttna:actn2-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    actn2bContained in: [BAC] CH211-248A14 (1) (order this), DKEY-13B19 (1) (order this)
    actn2bEncodes: [EST] fd44c03
    [cDNA] MGC:123223 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001037573 (1) 2986bp
    Genomic GenBank:BX005070 242955bp Blast at MegaBLAST
    Polypeptide UniProtKB:D1GJ55 (1) 895aa
    Sequence Clusters UniGene:80021 (1)
    Sequence Information (all 16)
    OTHER actn2b GENE PAGES 
  • Gene:641575 (1)
  • VEGA:OTTDARG00000022856 (1)
  • Ensembl(GRCz10):ENSDARG00000071090 (1)
  • ORTHOLOGY for actn2b (Chr: 17) 
    Species Symbol Chromosome Accession # Evidence
    Human ACTN2 1
  • Gene:88
  • OMIM:102573
  • HGNC:164
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (2)
    Functional complementation (1)
    Nucleotide sequence comparison (1)
    Mouse Actn2 13
  • MGI:109192
  • Gene:11472
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (21)