ZFIN ID: ZDB-GENE-051127-39
Gene Name: actinin, alpha 2b
Gene Symbol: actn2b

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: actn2, wu:fd44c03, zgc:123223

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adaxial cell, cerebellum, diencephalon, eye (all 25) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa274 Point Mutation Unknown Stop Loss, Premature Stop ENU
sa36379 Point Mutation Unknown Premature Stop ENU
sa36380 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42906 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-actn2b (1), MO2-actn2b (1), MO3-actn2b (1), MO4-actn2b (1), MO5-actn2b (1)
    PHENOTYPE
    Data: 11 figures from 2 publications
    Observed in: atrium, cardiac muscle myofibril, cardiac muscle cell sarcomere, cardiac muscle cell Z disc (all 24) expand
    DISEASE ASSOCIATED WITH actn2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1AA Cardiomyopathy, dilated, 1AA, with or without LVNC 612158
    Cardiomyopathy, hypertrophic, 23, with or without LVNC 612158
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process eye development (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001589 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR002017 (1)
  • InterPro:IPR002048 (1)
  • InterPro:IPR011992 (1)
  • InterPro:IPR014837 (1)
  • InterPro:IPR018159 (1)
  • PROSITE:PS00019 (1)
  • PROSITE:PS00020 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50222 (1)
  • Pfam:PF00307 (1)
  • Pfam:PF00435 (1)
  • Pfam:PF08726 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA actn2b-001 (1) 2986
    aberrant processed transcript actn2b-002 (1) 2470
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab1-actn2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM actn2b
    Tg(ttn.2:actn2-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    actn2bContained in: [BAC] CH211-248A14 (1) (order this), DKEY-13B19 (1) (order this)
    actn2bEncodes: [EST] fd44c03
    [cDNA] MGC:123223 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001037573 (1) 2986bp
    Genomic GenBank:BX005070 242955bp Blast at MegaBLAST
    Polypeptide UniProtKB:D1GJ55 (1) 895aa
    Sequence Clusters UniGene:80021 (1)
    Sequence Information (all 16)
    OTHER actn2b GENE PAGES
  • Gene:641575 (1)
  • VEGA:OTTDARG00000022856 (1)
  • Ensembl(GRCz10):ENSDARG00000071090 (1)
  • ORTHOLOGY for actn2b (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human ACTN2 1
  • Gene:88
  • OMIM:102573
  • HGNC:164
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (2)
    Functional complementation (1)
    Nucleotide sequence comparison (1)
    Mouse Actn2 13
  • MGI:109192
  • Gene:11472
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (24)