Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-051127-39
Gene Name: actinin, alpha 2
Gene Symbol: actn2
Previous Names: wu:fd44c03, zgc:123223
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adaxial cell, cerebellum, diencephalon, eye (all 25) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-actn2 (1), MO2-actn2 (1), MO3-actn2 (1), MO4-actn2 (1), MO5-actn2 (1)
PHENOTYPE
Data: 11 figures from 2 publications
Observed in: atrium, cardiac muscle myofibril, cardiac muscle cell sarcomere, cardiac muscle cell Z disc (all 24) expand

Phenotype of Human Orthologue OMIM Phenotype ID
?Cardiomyopathy, dilated, 1AA 612158
GENE ONTOLOGY
Ontology GO Term
Biological Process eye development (more)
Molecular Function actin binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001589 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR002017 (1)
  • InterPro:IPR002048 (1)
  • InterPro:IPR011992 (1)
  • InterPro:IPR014837 (1)
  • InterPro:IPR018159 (1)
  • PROSITE:PS00019 (1)
  • PROSITE:PS00020 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50222 (1)
  • Pfam:PF00307 (1)
  • Pfam:PF00435 (1)
  • Pfam:PF08726 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA actn2-001 (1) 2986
    aberrant processed transcript actn2-002 (1) 2470
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-actn2 (1)
    CONSTRUCTS WITH SEQUENCES FROM actn2
    Tg(ttna:actn2-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    actn2 Contained in: [BAC] CH211-248A14 (1) (order this), DKEY-13B19 (1)
    actn2 Encodes: [EST] fd44c03
    [cDNA] MGC:123223 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001037573 (1) 2986 bp
    Genomic GenBank:BX005070 242955 bp Blast at MegaBLAST
    Polypeptide UniProtKB:D1GJ55 (1) 895 aa
    Sequence Clusters UniGene:80021 (1)
    Sequence Information (all 16)
    OTHER actn2 GENE PAGES
  • Gene:641575 (1)
  • VEGA:OTTDARG00000022856 (1)
  • Ensembl(Zv9):ENSDARG00000071090 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL FC
    Zebrafish actn2 17  
    Human ACTN2 1 (1q42-q43)
  • OMIM:102573
  • Gene:88
  • Mouse Actn2 13 ( 4.54 cM)
  • MGI:109192
  • Gene:11472
  • Orthology Details
    CITATIONS (20)