ZFIN ID: ZDB-GENE-050517-43
Gene Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Symbol: tap1    Nomenclature History

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Previous Name: abcb2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled peptide antigen transmembrane transporter activity; MHC class I protein binding activity; and TAP2 binding activity. Predicted to be involved in peptide transport and transmembrane transport. Predicted to localize to MHC class I peptide loading complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; bone inflammation disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member).
Genome Resources: Alliance (1),  Gene:100333043 (1),  Ensembl(GRCz11):ENSDARG00000079766 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tap1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
MHC class I deficiency Alliance Bare lymphocyte syndrome, type I 604571
DISEASE ASSOCIATED WITH tap1 VIA EXPERIMENTAL MODELS No data available
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tap1-201 (1)    Ensembl 2577
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tap1 No data available
MARKER RELATIONSHIPS
tap1 Contained in: [BAC] CH73-31D8 (1), CH73-376G11 (1), CH211-214D1
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_002665007 (1) 2561 nt
Genomic GenBank:AL954130 235236 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A2R8Q3W5 (1) 736 aa
Sequence Information (all 10)
ORTHOLOGY for tap1 ( Chr: 16 )
CITATIONS (26)