Gene

abcb11b

ID
ZDB-GENE-050517-14
Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
Symbol
abcb11b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have ATPase-coupled transmembrane transporter activity and canalicular bile acid transmembrane transporter activity. Involved in bile acid secretion. Predicted to localize to integral component of membrane. Is expressed in liver. Used to study progressive familial intrahepatic cholestasis 2. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from Ellis et al., 2017
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Ellis et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcb11b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
benign recurrent intrahepatic cholestasis 2 Alliance Cholestasis, benign recurrent intrahepatic, 2 605479
progressive familial intrahepatic cholestasis 2 Alliance Cholestasis, progressive familial intrahepatic 2 601847
Associated With abcb11b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Family IPR039421 Type I protein exporter
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter, conserved site ABC transporter-like ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily P-loop containing nucleoside triphosphate hydrolase Type I protein exporter
UniProtKB:E7EZD3 1308
UniProtKB:A0A0R4IVE7 1279
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-abcb11 polyclonal Rabbit
  • IHC
Kamiya Biomedical Company
11
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations