ZFIN ID: ZDB-GENE-050517-14
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11b
Gene Symbol: abcb11b
Sequence Ontology ID : SO:0000704

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Location: Chr: 11 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ATP binding activity and ATPase activity, coupled to transmembrane movement of substances; predicted to be involved in transmembrane transport; predicted to localize to the integral  ...
GENE EXPRESSION
All Expression Data: 3 figures from Ellis et al., 2017
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ci200 Indel Exon 8 Frameshift, Premature Stop CRISPR
la017674Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6199 Point Mutation Unknown Splice Site ENU
    sa6200 Point Mutation Unknown Splice Site ENU
    Targeting reagents:
    PHENOTYPE
    Data: 5 figures from Ellis et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH abcb11b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    benign recurrent intrahepatic cholestasis 2 Cholestasis, benign recurrent intrahepatic, 2 605479
    intrahepatic cholestasis Cholestasis, benign recurrent intrahepatic, 2 605479
    Cholestasis, progressive familial intrahepatic 2 601847
    progressive familial intrahepatic cholestasis 2 Cholestasis, progressive familial intrahepatic 2 601847
    DISEASE ASSOCIATED WITH abcb11b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    progressive familial intrahepatic cholestasis 2 abcb11bci200/ci200 standard conditions Ellis et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bile acid secretion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR036640 (1)
  • InterPro:IPR039421 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA abcb11b-001 (1) 4463
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM abcb11b No data available
    MARKER RELATIONSHIPS
    abcb11bContained in: [BAC] DKEY-9A6 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_003199465 (1) 5038bp
    Genomic GenBank:BX004890 (1) 211406bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7EZD3 (1) 1308aa
    Sequence Clusters UniGene:117079 (1)
    Sequence Information (all 8)
    OTHER abcb11b GENE PAGES
  • Alliance (1)
  • Gene:571189 (1)
  • VEGA:OTTDARG00000042199 (1)
  • Ensembl(GRCz11):ENSDARG00000070078 (2)
  • ORTHOLOGY for abcb11b (Chr: 11)
    CITATIONS (25)