Gene

wt1b

ID
ZDB-GENE-050420-319
Name
WT1 transcription factor b
Symbol
wt1b Nomenclature History
Previous Names
  • si:ch211-160j6.3 (1)
  • zgc:152697 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; fin regeneration; and macrophage chemotaxis. Predicted to localize to cytoplasm and nuclear speck. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
38 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wt1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Denys-Drash syndrome Alliance Denys-Drash syndrome 194080
Frasier syndrome Alliance Frasier syndrome 136680
malignant mesothelioma Alliance Mesothelioma, somatic 156240
nephroblastoma Alliance Wilms tumor, type 1 194070
nephrotic syndrome type 4 Alliance Nephrotic syndrome, type 4 256370
Meacham syndrome 608978
Associated With wt1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000976 Wilm's tumour protein, N-terminal
Domain IPR013087 Zinc finger C2H2-type
Family IPR017987 Wilm's tumour protein
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Wilm's tumour protein Wilm's tumour protein, N-terminal Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q2QBW1 404
UniProtKB:Q08CU4 404
UniProtKB:Q1L884 412
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations