ZFIN ID: ZDB-GENE-050419-28
Gene Name: dynactin 1b
Gene Symbol: dctn1b    Nomenclature History

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Previous Names: mok2 (1), si:ch211-132e22.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have microtubule plus-end binding activity. Involved in camera-type eye photoreceptor cell differentiation. Predicted to localize to several cellular components, including axon; kinetochore; and microtubule cytoskeleton. Is expressed in anterior lateral line ganglion; brain; and posterior lateral line ganglion. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1).
Genome Resources: Alliance (1),  Gene:100003026 (1),  Ensembl(GRCz11):ENSDARG00000056753 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ic3035 Insertion Unknown Unknown CRISPR
nl17 Small Deletion Exon 3 Frameshift CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-dctn1b 1
CRISPR2-dctn1b 1
MO1-dctn1b N/A 1
MO2-dctn1b N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dctn1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 1 Alliance {Amyotrophic lateral sclerosis, susceptibility to} 105400
distal hereditary motor neuronopathy type 7B Alliance Neuronopathy, distal hereditary motor, type VIIB 607641
Perry syndrome Alliance Perry syndrome 168605
DISEASE ASSOCIATED WITH dctn1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye photoreceptor cell differentiation (more)
Cellular Component centrosome (more)
Molecular Function microtubule binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dctn1b-201 (1)    Ensembl 8610
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dctn1b No data available
MARKER RELATIONSHIPS
dctn1b Contained in: [BAC] CH211-132E22 (1), CH211-195E19 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_009307200 (1)
Genomic GenBank:CR559945 (1) 186151 nt
Select Tool
Polypeptide UniProtKB:F6PC33 (1) 1258 aa
Sequence Information (all 24)
ORTHOLOGY for dctn1b ( Chr: 13 )
CITATIONS (20)