ZFIN ID: ZDB-GENE-050407-1
Gene Name: fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Gene Symbol: flt1
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: flt1a (1), VEGFR1

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(Including Attributions)
Location: Chr: 24 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have transmembrane receptor protein tyrosine kinase activity; involved in blood vessel development, blood vessel morphogenesis, and regulation of heart contraction; predicted to localize  ...
GENE EXPRESSION
All Expression Data: 28 figures from 24 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns29 Indel Exon 3 Premature Stop CRISPR
fh338 Point Mutation Unknown Unknown ENU
fh390 Unknown Unknown Unknown
flt1_unrecovered Point Mutation Unknown Unknown ENU
ka601 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka602 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka603 Insertion Exon 3 Frameshift, Premature Stop CRISPR
ka604 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka605 Insertion Exon 11 Frameshift, Premature Stop CRISPR
ka606 Insertion Exon 11 Frameshift, Premature Stop CRISPR
ka607 Small Deletion Exon 11 Frameshift, Premature Stop CRISPR
ka608 Indel Unknown Unknown CRISPR
sa301 Point Mutation Unknown Premature Stop ENU
sa1504 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12242 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15078 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30092 Point Mutation Unknown Splice Site ENU
    sa37885 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37886 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39448 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 16 figures from 7 publications
    Observed in:
    DISEASE ASSOCIATED WITH flt1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH flt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009135 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR036179 (1)
  • InterPro:IPR041348 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF17988 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA flt1-201 (1) 4251
    flt1-202 (1) 2858
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM flt1
    MARKER RELATIONSHIPS
    flt1Contained in: [BAC] CH211-140B10 (1) (order this), DKEY-33C18 (1) (order this)
    flt1Encodes: [cDNA] MGC:162053 (1) (order this), MGC:195349 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014829 (1) 4220bp
    Genomic GenBank:BX571696 (1) 171175bp
    Select Tool
    Polypeptide UniProtKB:B3DKP1 (1) 1272aa
    Sequence Clusters UniGene:87605 (1)
    Sequence Information (all 27)
    OTHER flt1 GENE PAGES
  • Alliance (1)
  • Gene:544667 (1)
  • VEGA:OTTDARG00000021355 (1)
  • ORTHOLOGY for flt1 (Chr: 24)
    CITATIONS (101)