Gene

flt1

ID
ZDB-GENE-050407-1
Name
fms related receptor tyrosine kinase 1
Symbol
flt1 Nomenclature History
Previous Names
  • flt1a (1)
  • VEGFR1
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in blood vessel development; establishment of left/right asymmetry; and regulation of heart contraction. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in angioblastic mesenchymal cell; brain; cardiovascular system; endothelial cell; and somite. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flt1 Human Ortholog
No data available
Associated With flt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041348 VEGFR-2, Transmembrane domain
Family IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site Vascular endothelial growth factor receptor 1 (VEGFR1) VEGFR-2, Transmembrane domain
UniProtKB:Q5GIT3 1272
UniProtKB:A4QNT7 473
UniProtKB:Q4JDD5 1272
UniProtKB:B3DKP1 1272
UniProtKB:F1QBD0 473
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-flt1 polyclonal IgG Rabbit
  • IHC
Thermo Fisher Scientific (Lab Vision)
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations