ZFIN ID: ZDB-GENE-050407-1
Gene Name: fms related receptor tyrosine kinase 1
Gene Symbol: flt1    Nomenclature History

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Previous Names: flt1a (1), VEGFR1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have vascular endothelial growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in blood vessel development; establishment of left/right asymmetry; and regulation of heart contraction. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in angioblastic mesenchymal cell; brain; cardiovascular system; endothelial cell; and somite. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).
Genome Resources: Alliance (1),  Gene:544667 (1),  Ensembl(GRCz11):ENSDARG00000019371 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns29 Indel Exon 3 Premature Stop CRISPR
fh338 Point Mutation Unknown Unknown ENU
fh390 Unknown Unknown Unknown
flt1_unrecovered Point Mutation Unknown Unknown ENU
ka601 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka602 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka603 Insertion Exon 3 Frameshift, Premature Stop CRISPR
ka604 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
ka605 Insertion Exon 11 Frameshift, Premature Stop CRISPR
ka606 Insertion Exon 11 Frameshift, Premature Stop CRISPR
ka607 Small Deletion Exon 11 Frameshift, Premature Stop CRISPR
ka608 Indel Unknown Unknown CRISPR
sa301 Point Mutation Unknown Premature Stop ENU
sa1504 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12242 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15078 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30092 Point Mutation Unknown Splice Site ENU
    sa37885 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37886 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39448 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH flt1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH flt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flt1-201 (1)    Ensembl 4251
    flt1-202 (1)    Ensembl 2858
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-flt1 polyclonal IgG Rabbit IHC Thermo Fisher Scientific (Lab Vision)
    3
    CONSTRUCTS WITH SEQUENCES FROM flt1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-0.8flt1:RFP) flt1 RFP Danio rerio 1 36
    Tg(flt1:EGFP) flt1 EGFP Danio rerio 1 1
    Tg(flt1:mCherry) flt1 mCherry Danio rerio 1 2
    Tg(flt1:Mmu.Fos-EGFP) flt1 EGFP Danio rerioMus musculus 1 5
    tg(flt1:nls-mcherry) flt1 mCherryNLS Danio rerio 1 1
    Tg(hsp70l:flt1,cryaa:Cerulean) cryaahsp70l Ceruleanflt1 Danio rerio 1 3
    tg(ins:tagrfpt-2a-flt1) ins 2Aflt1TagRFPT Danio rerio 1 1
    TgBAC(flt1:YFP) flt1 YFP Danio rerio 1 26
    MARKER RELATIONSHIPS
    flt1 Contained in: [BAC] CH211-140B10 (1), DKEY-33C18 (1) (order this)
    flt1 Encodes: [cDNA] MGC:162053 (1), MGC:195349 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014829 (1) 4220 nt
    Genomic GenBank:BX571696 (1) 171175 nt
    Select Tool
    Polypeptide UniProtKB:B3DKP1 (1) 1272 aa
    Sequence Information (all 26)
    ORTHOLOGY for flt1 ( Chr: 24 )
    CITATIONS (123)