Gene

islr2

ID

ZDB-GENE-050320-95

Name

immunoglobulin superfamily containing leucine-rich repeat 2

Symbol

islr2 Nomenclature History

Previous Names

zgc:101901

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Involved in retinal ganglion cell axon guidance. Predicted to localize to integral component of membrane. Is expressed in nervous system. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

IMAGE:7162555 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Panza et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With islr2 Human Ortholog

No data available

Associated With islr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype