Gene
tcf7
- ID
- ZDB-GENE-050222-4
- Name
- transcription factor 7
- Symbol
- tcf7 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within pectoral fin development and spinal cord dorsal/ventral patterning. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in several structures, including dermal bone; nervous system; optic cup; pectoral fin bud; and prechordal plate. Orthologous to human TCF7 (transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Family | IPR028785 | Transcription factor 7 |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
Domain Details Per Protein
| Protein | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor 7 | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W5T7
|
235 | ||||||
|
UniProtKB:A5A8K1
|
333 | ||||||
|
UniProtKB:F8W4S5
|
239 | ||||||
|
UniProtKB:F1RAG0
|
239 | ||||||
|
UniProtKB:Q5PU94
|
355 | ||||||
|
UniProtKB:F1QZD5
|
267 | ||||||
|
UniProtKB:F8W2J8
|
217 | ||||||
|
UniProtKB:Q5PU93
|
355 | ||||||
|
UniProtKB:B3DIS1
|
351 | ||||||
|
UniProtKB:X1WDF3
|
355 | ||||||
|
UniProtKB:Q5PU92
|
19 | ||||||
|
UniProtKB:A0A2R8QK61
|
333 | ||||||
|
UniProtKB:A0A2R8Q6H8
|
354 |
Interactions and Pathways
No data available
Plasmids
No data available