ZFIN Gene: tcf7

ZFIN ID: ZDB-GENE-050222-4

ZFIN ID: ZDB-GENE-050222-4

Gene Name:

transcription factor 7

Gene Symbol:

tcf7

Sequence Ontology ID :

SO:0000704

Previous Name:

Location:

Chr: 21 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have DNA-binding transcription factor activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in pectoral fin ...

GENE EXPRESSION
All Expression Data:	16 figures from 10 publications
Wild-type Stages, Structures:	Cleavage:4-cell (1.0h-1.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	apical ectodermal ridge pectoral fin bud branchiostegal ray 3 cleithrum diencephalon fin fold pectoral fin bud germ ring head hindbrain hypoblast intestinal epithelium liver maxilla median fin fold midbrain neural rod neural rod notochord opercle optic cup optic tectum otic vesicle pectoral fin pectoral fin bud polster posterior lateral line primordium prechordal plate presumptive diencephalon presumptive neural retina spinal cord tail bud unspecified whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen
hu3238	Point Mutation	Exon 2	Premature Stop	ENU
nkhg21cEt	Transgenic Insertion	Unknown	Unknown	DNA
sa1057	Point Mutation	Unknown	Splice Site	ENU

Targeting reagents:

MO1-tcf7 (1)
MO2-tcf7 (1)

PHENOTYPE

Data:	3 figures from 3 publications
Observed in:	brain cell population proliferation midbrain pectoral fin

DISEASE ASSOCIATED WITH tcf7 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH tcf7 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of transcription by RNA polymerase II (more)
Cellular Component	nucleus (more)
Molecular Function	DNA-binding transcription factor activity, RNA polymerase II-specific (more)

GO Terms (all 16)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR009071 (1) InterPro:IPR013558 (1) InterPro:IPR024940 (1) InterPro:IPR027397 (1) InterPro:IPR028785 (1) InterPro:IPR036910 (1)	PROSITE:PS50118 (1)	Pfam:PF00505 (1) Pfam:PF08347 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	tcf7-201 (1)	803	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7-202 (1)	924	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7-203 (1)	939	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7-204 (1)	767	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7-205 (1)	792	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM tcf7 No data available

MARKER RELATIONSHIPS

tcf7Contained in:	[BAC] CH73-202G8 (1) (order this)
tcf7Encodes:	[cDNA] MGC:194208 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001012389 (1)	1349bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU639470 (1)	114638bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5PU93 (1)	355aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:134827 (1)

Sequence Information (all 31)

OTHER tcf7 GENE PAGES

Alliance (1)

Gene:497649 (1)

VEGA:OTTDARG00000034852 (1)

Ensembl(GRCz11):ENSDARG00000038672 (2)

ORTHOLOGY for tcf7 (Chr: 21)

CITATIONS (53)

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