ZFIN ID: ZDB-GENE-050208-661
Gene Name: complement factor H
Gene Symbol: cfh    Nomenclature History

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Previous Names: im:7147412, si:ch211-207o17.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Is expressed in several structures, including digestive system; eye; fin; gill; and heart. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H).
Genome Resources: Alliance (1),  Gene:553297 (1),  Ensembl(GRCz11):ENSDARG00000100442 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7147412]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7495 Point Mutation Unknown Missense ENU
sa29783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29784 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cfh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 4 Alliance {Macular degeneration, age-related, 4} 610698
    basal laminar drusen Alliance Basal laminar drusen 126700
    Complement factor H deficiency 609814
    {Hemolytic uremic syndrome, atypical, susceptibility to, 1} 235400
    DISEASE ASSOCIATED WITH cfh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biological_process (more)
    Cellular Component cellular_component (more)
    Molecular Function molecular_function (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cfh-201 (1)    Ensembl 708
    cfh-202 (1)    Ensembl 1838
    cfh-204 (1)    Ensembl 2997
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cfh No data available
    MARKER RELATIONSHIPS
    cfh Contained in: [BAC] CH211-207O17 (1)
    cfh Encodes: [EST] IMAGE:7147412 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001199190 (1) 2925 nt
    Genomic GenBank:BX005398 (1) 209859 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IPQ8 (1) 901 aa
    Sequence Information (all 19)
    ORTHOLOGY for cfh ( Chr: 22 )
    CITATIONS (20)