ZFIN ID: ZDB-GENE-050208-597
Gene Name: guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
Gene Symbol: gna11a    Nomenclature History

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Previous Names: G11-2 (1), gna11, Galpha 11b (1), si:dkey-42p8.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating dopamine receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in barbel; brain; gill; lip; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11).
Genome Resources: Alliance (1),  Gene:563953 (1),  Ensembl(GRCz11):ENSDARG00000010002 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3183 Point Mutation Unknown Splice Site ENU
sa3194 Point Mutation Unknown Premature Stop ENU
sa5691 Point Mutation Unknown Premature Stop ENU
sa5692 Point Mutation Unknown Splice Site ENU
sa37508 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gna11a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant hypocalcemia 2 Alliance Hypocalcemia, autosomal dominant 2 615361
    familial hypocalciuric hypercalcemia 2 Alliance Hypocalciuric hypercalcemia, type II 145981
    DISEASE ASSOCIATED WITH gna11a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component heterotrimeric G-protein complex (more)
    Molecular Function G-protein beta/gamma-subunit complex binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gna11a-201 (1)    Ensembl 1139
    gna11a-202 (1)    Ensembl 1199
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gna11a No data available
    MARKER RELATIONSHIPS
    gna11a Contained in: [BAC] CH211-207C7 (1), DKEY-42P8 (1) (order this)
    gna11a Encodes: [cDNA] MGC:194400 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045036 (1) 1333 nt
    Genomic GenBank:AL953843 (1) 212575 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8RHQ9 (1) 402 aa
    Sequence Information (all 21)
    ORTHOLOGY for gna11a ( Chr: 22 )
    CITATIONS (22)