Gene

gna11a

ID
ZDB-GENE-050208-597
Name
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
Symbol
gna11a Nomenclature History
Previous Names
  • G11-2 (1)
  • gna11
  • Galpha 11b (1)
  • si:dkey-42p8.2
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have G-protein beta/gamma-subunit complex binding activity; GTPase activity; and type 2A serotonin receptor binding activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in barbel; brain; gill; lip; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gna11a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypocalcemia, autosomal dominant 2 615361
Hypocalciuric hypercalcemia, type II 145981
Associated With gna11a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000654 G-protein alpha subunit, group Q
Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length G-protein alpha subunit, group Q G protein alpha subunit, helical insertion Guanine nucleotide binding protein (G-protein), alpha subunit P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9PVA9 270
UniProtKB:B3DI16 359
UniProtKB:A0A0R4IEQ0 400
UniProtKB:F6PAM1 359
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations