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ZIRC
ZFIN ID: ZDB-GENE-041210-359
Gene Name: SH2B adaptor protein 3
Gene Symbol: sh2b3    Nomenclature History

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Previous Names: DKEYP-10C7.2, si:dkeyp-1e8.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Orthologous to human SH2B3 (SH2B adaptor protein 3).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000069958 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sh2b3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential thrombocythemia Alliance Thrombocythemia, somatic 187950
familial erythrocytosis 1 Alliance Erythrocytosis, somatic 133100
myelofibrosis Alliance Myelofibrosis, somatic 254450
DISEASE ASSOCIATED WITH sh2b3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hemopoiesis (more)
Cellular Component plasma membrane (more)
Molecular Function signaling adaptor activity (more)
GO Terms (all 6)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sh2b3-202 (1)    Ensembl 1791
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sh2b3 No data available
MARKER RELATIONSHIPS
sh2b3 Contained in: [BAC] DKEYP-1E8 (1), DKEYP-10C7
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
Genomic GenBank:BX571679 (1) 171155 bp
Select Tool
Polypeptide UniProtKB:F6P9Y8 (1) 596 aa
Sequence Information (all 5)
ORTHOLOGY for sh2b3 ( Chr: 5 )
CITATIONS (12)