Gene
pparaa
- ID
- ZDB-GENE-041210-169
- Name
- peroxisome proliferator-activated receptor alpha a
- Symbol
- pparaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in several processes, including hormone-mediated signaling pathway; negative regulation of inflammatory response; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and spinal cord neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017612 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Hyperapobetalipoproteinemia, susceptibility to} |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Family | IPR001723 | Nuclear hormone receptor |
Family | IPR003074 | Peroxisome proliferator-activated receptor |
Family | IPR003076 | Peroxisome proliferator-activated receptor alpha |
Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|---|
UniProtKB:O42548
|
31 | |||||||
UniProtKB:Q5RGZ2
|
470 | |||||||
UniProtKB:Q1L694
|
473 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
pparaa-201
(1)
|
1953 nt |
Interactions and Pathways
Plasmids
No data available