Gene

pparaa

ID

ZDB-GENE-041210-169

Name

peroxisome proliferator-activated receptor alpha a

Symbol

pparaa Nomenclature History

Previous Names

PPAR[a](III)
ppara2 (1)
ppara3
ppara
NR1C1-A (1)
nr1c1a (1)
PPARalpha-A (1)
si:ch211-239e6.3

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of cholesterol storage; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and spinal cord neural tube. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

dq017612 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pparaa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Hyperapobetalipoproteinemia, susceptibility to}

Associated With pparaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001723	Nuclear hormone receptor
Family	IPR003074	Peroxisome proliferator-activated receptor
Family	IPR003076	Peroxisome proliferator-activated receptor alpha
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily