ZFIN ID: ZDB-GENE-041114-63
Gene Name: nuclear receptor subfamily 2, group E, member 3
Gene Symbol: nr2e3    Nomenclature History

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Previous Names: NR2D2 (1), fj55b07, PNR (1), wu:fj55b07, zgc:103631

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in pineal gland development. Localizes to the nucleus. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is expressed in several structures, including diencephalon; optic vesicle; presumptive diencephalon; presumptive neural retina; and retina. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3).
Genome Resources: Alliance (1),  Gene:492496 (1),  Ensembl(GRCz11):ENSDARG00000045904 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh342 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh343 Point Mutation Unknown Unknown ENU
    hzu9 Small Deletion Exon 4 Unknown CRISPR
    nr2e3_unrecovered Point Mutation Unknown Unknown ENU
    sa15662 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30255 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nr2e3 2
    MO1-nr2e3 N/A 1
    MO2-nr2e3 N/A 2
    DISEASE ASSOCIATED WITH nr2e3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    enhanced S-cone syndrome Alliance Enhanced S-cone syndrome 268100
    retinitis pigmentosa 37 Alliance Retinitis pigmentosa 37 611131
    DISEASE ASSOCIATED WITH nr2e3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pineal gland development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr2e3-201 (1)    Ensembl 2072
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nr2e3 polyclonal Rabbit IHC 4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr2e3 No data available
    MARKER RELATIONSHIPS
    nr2e3 Contained in: [BAC] DKEYP-91C1 (1)
    nr2e3 Encodes: [EST] fj55b07
    [cDNA] MGC:103631 (1), MGC:173759 (1), MGC:191964 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007368 (1) 2079 nt
    Genomic GenBank:AL929050 (1) 196743 nt
    Select Tool
    Polypeptide UniProtKB:F1QGF3 (1) 426 aa
    Sequence Information (all 23)
    ORTHOLOGY for nr2e3 ( Chr: 25 )
    CITATIONS (48)