ZFIN ID: ZDB-GENE-091204-125
Gene Name: diphosphoinositol pentakisphosphate kinase 2
Gene Symbol: ppip5k2    Nomenclature History

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Previous Names: im:7137778, si:dkey-117i20.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have diphosphoinositol-pentakisphosphate kinase activity; inositol heptakisphosphate kinase activity; and inositol hexakisphosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2).
Genome Resources: Alliance (1),  Gene:449862 (1),  Ensembl(GRCz11):ENSDARG00000078441 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137778]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ppip5k2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 100 Alliance Deafness, autosomal recessive 100 618422
DISEASE ASSOCIATED WITH ppip5k2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component cytoplasm (more)
Molecular Function 5-diphosphoinositol pentakisphosphate 3-kinase activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR033379 Histidine acid phosphatase active site
Domain IPR040557 VIP1, N-terminal
Family IPR000560 Histidine phosphatase superfamily, clade-2
Family IPR037446 Histidine acid phosphatase, VIP1 family
Homologous_superfamily IPR029033 Histidine phosphatase superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript ppip5k2-205 (1)    Ensembl 795
mRNA ppip5k2-206 (1)    Ensembl 5059
ncRNA ppip5k2-002 (1)    Ensembl 327
ppip5k2-003 (1)    Ensembl 429
ppip5k2-005 (1)    Ensembl 530
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ppip5k2 No data available
MARKER RELATIONSHIPS
ppip5k2 Contained in: [BAC] DKEY-117I20 (1) (order this)
ppip5k2 Encodes: [EST] IMAGE:7137778 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005156456 (1) 5791 nt
Genomic GenBank:BX571726 (1) 106819 nt
Select Tool
Polypeptide UniProtKB:E7F712 (1) 1303 aa
Sequence Information (all 30)
ORTHOLOGY for ppip5k2 ( Chr: 10 )
CITATIONS (19)