Gene
ccn6
- ID
- ZDB-GENE-041001-86
- Name
- cellular communication network factor 6
- Symbol
- ccn6 Nomenclature History
- Previous Names
-
- si:dkey-119m7.6
- wisp3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have heparin binding activity and integrin binding activity. Involved in several processes, including cartilage development; negative regulation of Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to localize to extracellular matrix. Human ortholog(s) of this gene implicated in progressive pseudorheumatoid arthropathy of childhood. Is expressed in otic vesicle; swim bladder; and ventricular zone. Orthologous to human CCN6 (cellular communication network factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| progressive pseudorheumatoid arthropathy of childhood | Alliance | Progressive pseudorheumatoid dysplasia | 208230 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR006208 | Glycoprotein hormone subunit beta |
| Domain | IPR043973 | CCN, TSP1 domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Length | CCN, TSP1 domain | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:D0E2W2
|
338 | ||||||||
|
UniProtKB:A0A8M6YUV4
|
331 |
Interactions and Pathways
No data available
Plasmids
No data available