ZFIN ID: ZDB-GENE-040426-2848
Gene Name: hexokinase 1
Gene Symbol: hk1    Nomenclature History

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Previous Names: DrHXK1 (1), im:7148527, wu:fc09d08, wu:fc16e02, wu:fc21e02, wu:fq14b11, zgc:55790 (1), zgc:77618

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Predicted to be involved in cellular glucose homeostasis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol and mitochondrion. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1).
Genome Resources: Alliance (1),  Gene:406791 (1),  Ensembl(GRCz11):ENSDARG00000039452 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018460Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28104 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42187 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hk1
    1
    CRISPR2-hk1
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hk1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 4G Alliance Neuropathy, hereditary motor and sensory, Russe type 605285
    Hemolytic anemia due to hexokinase deficiency 235700
    Neurodevelopmental disorder with visual defects and brain anomalies 618547
    Retinitis pigmentosa 79 617460
    DISEASE ASSOCIATED WITH hk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component cytosol (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hk1-201 (1)    Ensembl 4061
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hk1 No data available
    MARKER RELATIONSHIPS
    hk1 Contained in: [BAC] CH211-1N9 (1), DKEY-226B20 (1) (order this)
    hk1 Encodes: [EST] fc09d08 (1), fc16e02 (1), fc21e02 (1), fq14b11 (1) (order this), IMAGE:7148527 (1)
    [cDNA] MGC:55790 (1), MGC:77618 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213252 (1) 4079 nt
    Genomic GenBank:BX546482 (1) 206949 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6NX09 (1) 918 aa
    Sequence Information (all 22)
    ORTHOLOGY for hk1 ( Chr: 13 )
    CITATIONS (50)