ZFIN ID: ZDB-GENE-040426-2848
Gene Name: hexokinase 1
Gene Symbol: hk1

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Previous Names: DrHXK1 (1), im:7148527, wu:fc09d08, wu:fc16e02, wu:fc21e02, wu:fq14b11, zgc:55790 (1), zgc:77618

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 18 figures from 4 publications
Directly Submitted Expression Data: 6 figures (18 images) from Thisse et al., 2004 [IMAGE:7148527]
  4 figures (13 images) from Rauch et al., 2003 [fq14b11]
  6 figures (18 images) from Thisse et al., 2004 [MGC:77618]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  adaxial cell, basal plate midbrain region, brain, central nervous system (all 30) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018460Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28104 Point Mutation Unknown Splice Site ENU
    sa42187 Point Mutation Unknown Splice Site ENU
    Targeting reagents: CRISPR1-hk1 (1), CRISPR2-hk1 (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hk1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 4G Neuropathy, hereditary motor and sensory, Russe type 605285
    Hemolytic anemia due to hexokinase deficiency 235700
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component cytosol (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001312 (1)
  • InterPro:IPR019807 (1)
  • InterPro:IPR022672 (1)
  • InterPro:IPR022673 (1)
  • PROSITE:PS00378 (1)
  • PROSITE:PS51748 (1)
  • Pfam:PF00349 (1)
  • Pfam:PF03727 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hk1-001 (1) 4061
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM hk1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hk1Contained in: [BAC] CH211-1N9 (1) (order this), DKEY-226B20 (1) (order this)
    hk1Encodes: [EST] fc09d08 (1), fc16e02 (1), fc21e02 (1), fq14b11 (1) (order this), IMAGE:7148527 (1) (order this)
    [cDNA] MGC:55790 (1) (order this), MGC:77618 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213252 (1) 4079bp
    Genomic GenBank:BX546482 (1) 206949bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJT7 (1) 919aa
    Sequence Clusters UniGene:9278 (1)
    Sequence Information (all 22)
    OTHER hk1 GENE PAGES
  • Gene:406791 (1)
  • VEGA:OTTDARG00000022817 (1)
  • Ensembl(GRCz10):ENSDARG00000039452 (1)
  • ORTHOLOGY for hk1 (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human HK1 10
  • Gene:3098
  • OMIM:142600
  • HGNC:4922
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Hk1 10
  • MGI:96103
  • Gene:15275
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (26)