ZFIN ID: ZDB-GENE-040426-1558
Gene Name: serine hydroxymethyltransferase 1 (soluble)
Gene Symbol: shmt1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: zSHMT-1 (1), zgc:66171 (1), zgc:77524

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits glycine hydroxymethyltransferase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to tetrahydrofolate; and protein homotetramerization. Localizes to cytosol and nucleus. Is expressed in several structures, including digestive system; immature eye; midbrain; neural tube; and oocyte. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1).
Genome Resources: Alliance (1),  Gene:394021 (1),  Ensembl(GRCz11):ENSDARG00000052816 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa26132 Point Mutation Unknown Splice Site, Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH shmt1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH shmt1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glycine biosynthetic process from serine (more)
Cellular Component cytosol (more)
Molecular Function glycine hydroxymethyltransferase activity (more)
GO Terms (all 26)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA shmt1-201 (1)    Ensembl 1858
shmt1-202 (1)    Ensembl 759
shmt1-203 (1)    Ensembl 794
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM shmt1 No data available
MARKER RELATIONSHIPS
shmt1 Contained in: [BAC] CH211-198M12 (1)
shmt1 Encodes: [EST] IMAGE:5916288, IMAGE:6910517 (1)
[cDNA] MGC:66171 (1), MGC:77524
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201046 (1) 1797 nt
Genomic GenBank:BX649440 (1) 29954 nt
Select Tool
Polypeptide UniProtKB:Q2TL58 (1) 481 aa
Sequence Information (all 23)
ORTHOLOGY for shmt1 ( Chr: 3 )
CITATIONS (31)