Gene

rtn4ip1

ID

ZDB-GENE-040426-1314

Name

reticulon 4 interacting protein 1

Symbol

rtn4ip1 Nomenclature History

Previous Names

zgc:63964

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have oxidoreductase activity. Involved in eye photoreceptor cell development and retina layer formation. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:63964 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Angebault et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rtn4ip1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
optic atrophy 10	Alliance	Optic atrophy 10 with or without ataxia, impaired intellectual development and seizures	616732

Associated With rtn4ip1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013154	Alcohol dehydrogenase-like, N-terminal
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Family	IPR037397	Reticulon-4-interacting protein 1
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily