Gene

tlr4bb

ID
ZDB-GENE-040219-9
Name
toll-like receptor 4b, duplicate b
Symbol
tlr4bb Nomenclature History
Previous Names
  • TIR4.2 (1)
  • tlr4b (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have signaling receptor activity. Involved in positive regulation of hematopoietic progenitor cell differentiation. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in several structures, including blood; forebrain neural keel; nervous system; neural rod; and yolk syncytial layer. Orthologous to human TLR4 (toll like receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from He et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr4bb Human Ortholog
No data available
Associated With tlr4bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Family IPR017241 Toll-like receptor
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor
UniProtKB:A0A2R8QLW9 702
UniProtKB:Q6TS41 819
UniProtKB:B8A691 819
UniProtKB:Q6TQH9 164
UniProtKB:Q6NV08 817
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Authors in Sullivan C et al (ZDB-PUB-091023-26) state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.
Citations