Gene

tlr3

ID
ZDB-GENE-040219-7
Name
toll-like receptor 3
Symbol
tlr3 Nomenclature History
Previous Names
  • zgc:123006
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have signaling receptor activity. Involved in response to bacterium and response to virus. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3).
Genome Resources
Note
None
Expression
All Expression Data
23 figures from 14 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 2} 613002
{HIV1 infection, resistance to} 609423
Associated With tlr3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR041015 Toll-like receptor 3 trans-membrane domain
Family IPR017241 Toll-like receptor
Family IPR027173 Toll-like receptor 3
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Cysteine-rich flanking region, C-terminal Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor Toll-like receptor 3 Toll-like receptor 3 trans-membrane domain
UniProtKB:Q6IWL5 903
UniProtKB:Q32PW5 903
UniProtKB:A0A2R8RPU1 902
UniProtKB:Q6TQI1 181
UniProtKB:B8JIL3 903
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations