ZFIN ID: ZDB-GENE-031116-52
Gene Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Gene Symbol: itga5    Nomenclature History

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Previous Names: bfe (1), before eight (1), sb:cb665, wu:fe02h07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits fibronectin binding activity and protein heterodimerization activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; chordate embryonic development; and lens fiber cell morphogenesis. Predicted to localize to the integrin complex. Is expressed in several structures, including brain; ectoderm; head; mesoderm; and trunk. Orthologous to human ITGA5 (integrin subunit alpha 5).
Genome Resources: Alliance (1),  Gene:386787 (1),  Ensembl(GRCz11):ENSDARG00000006353 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b926 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • cu20 Small Deletion Unknown Unknown CRISPR
    itga5_unspecified Unspecified Unknown Unknown
    kt293 Small Deletion Unknown Frameshift ENU
    kt451 Point Mutation Donor Splice Site of Intron 4 Unknown ENU
    kt664 Unknown Unknown Unknown ENU
    la014415Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022674Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022675Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022676Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13598 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13837 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44025 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tbfe1 Point Mutation Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tbfe2 Point Mutation Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itga5 1
    CRISPR2-itga5
    1
    MO1-itga5 N/A 5
    MO2-itga5 N/A 2
    MO3-itga5 N/A 2
    MO4-itga5 N/A 2
    MO5-itga5 N/A 1
    DISEASE ASSOCIATED WITH itga5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH itga5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    Domain IPR013649 Integrin alpha-2
    Family IPR000413 Integrin alpha chain
    Homologous_superfamily IPR028994 Integrin alpha, N-terminal
    Homologous_superfamily IPR032695 Integrin domain superfamily
    Repeat IPR013517 FG-GAP repeat
    Repeat IPR013519 Integrin alpha beta-propellor
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itga5-201 (1)    Ensembl 5405
    ncRNA itga5-002 (1)    Ensembl 676
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga5
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tbx16l:itga5-RFP) tbx16l itga5RFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    itga5 Contained in: [BAC] DKEY-27M20 (1) (order this), DKEY-32G6 (1) (order this), DKEY-220D15 (1) (order this)
    itga5 Encodes: [EST] cb665 (1) (order this), fe02h07 (1)
    [cDNA] MGC:195021 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004288 (1) 3737 nt
    Genomic GenBank:CR293512 (1) 127255 nt
    Select Tool
    Polypeptide UniProtKB:Q5I2A9 (1) 1053 aa
    Sequence Information (all 22)
    ORTHOLOGY for itga5 ( Chr: 23 )
    CITATIONS (64)