ZFIN ID: ZDB-GENE-031002-33
Gene Name: profilin 1
Gene Symbol: pfn1    Nomenclature History

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Previous Names: fa91a03, sb:cb813 (1), wu:fa91a03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have actin binding activity. Involved in convergent extension involved in gastrulation and epiboly involved in gastrulation with mouth forming second. Predicted to localize to cytoplasm. Is expressed in several structures, including EVL; blood vessel; hatching gland; periderm; and pharynx. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1).
Genome Resources: Alliance (1),  Gene:799355 (1),  Ensembl(GRCz11):ENSDARG00000088091 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pfn1 N/A 1
DISEASE ASSOCIATED WITH pfn1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 18 Alliance Amyotrophic lateral sclerosis 18 614808
DISEASE ASSOCIATED WITH pfn1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process convergent extension involved in gastrulation (more)
Cellular Component cytoplasm (more)
Molecular Function actin binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pfn1-201 (1)    Ensembl 972
ncRNA pfn1-002 (1)    Ensembl 570
pfn1-003 (1)    Ensembl 446
pfn1-004 (1)    Ensembl 847
pfn1-005 (1)    Ensembl 1028
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pfn1 No data available
MARKER RELATIONSHIPS
pfn1 Contained in: [Fosmid] CH1073-89L17 (1)
pfn1 Contains: [STS] chunp30047
pfn1 Encodes: [EST] cb813 (1) (order this), fa91a03
pfn1 Has Artifact: [EST] fa99f04
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001305588 (1)
Genomic GenBank:CU633889 (1) 36169 nt
Select Tool
Polypeptide UniProtKB:E7F0A1 (1) 141 aa
Sequence Information (all 19)
ORTHOLOGY for pfn1 ( Chr: 23 )
CITATIONS (22)