Gene

pfn1

ID
ZDB-GENE-031002-33
Name
profilin 1
Symbol
pfn1 Nomenclature History
Previous Names
  • fa91a03
  • sb:cb813 (1)
  • wu:fa91a03 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have actin binding activity. Involved in convergent extension involved in gastrulation and epiboly involved in gastrulation with mouth forming second. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Is expressed in several structures, including EVL; blood vessel; hatching gland; periderm; and pharynx. Orthologous to human PFN1 (profilin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lai et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pfn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 18 Alliance Amyotrophic lateral sclerosis 18 614808
Associated With pfn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR005454 Profilin1/2/3, vertebrate
Family IPR005455 Profilin
Family IPR029891 Profilin-2
Homologous_superfamily IPR036140 Profilin superfamily
Domain Details Per Protein
Protein Length Profilin Profilin1/2/3, vertebrate Profilin-2 Profilin superfamily
UniProtKB:E7F0A1 141
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations