ZFIN ID: ZDB-GENE-030805-5
Gene Name: T-box 1
Gene Symbol: tbx1
Previous Names: mp:zf637-3-000616, van gogh, vgo, zgc:136724
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 45 figures from 30 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  anterior lateral plate mesoderm, anterior semicircular canal, atrioventricular canal, atrium (all 32) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tm208 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tu285 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-tbx1 (1), MO2-tbx1 (1), MO3-tbx1 (1), MO4-tbx1 (1), MO5-tbx1 (1)
    PHENOTYPE
    Data: 39 figures from 12 publications
    Observed in: anatomical system, anterior crista primordium, aortic arch, atrium (all 69) expand
    DISEASE ASSOCIATED WITH tbx1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    DiGeorge syndrome DiGeorge syndrome 188400
    double outlet right ventricle Conotruncal anomaly face syndrome 217095
    tetralogy of Fallot Tetralogy of Fallot 187500
    velocardiofacial syndrome Velocardiofacial syndrome 192430
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart looping (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001699 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR018186 (1)
  • PROSITE:PS01264 (1)
  • PROSITE:PS01283 (1)
  • PROSITE:PS50252 (1)
  • Pfam:PF00907 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    antisense ottdart00000060017 (1) 1006
    mRNA tbx1-001 (1) 2343
    tbx1-002 (1) 1500
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tbx1
    Tg(nkx2.3:tbx1,myl7:EGFP), Tg(nkx2.5:tbx1,cryaa:Cerulean)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tbx1Contained in: [BAC] DKEY-27E18 (1) (order this)
    tbx1Encodes: [EST] zf637-3-000616 (1)
    [cDNA] MGC:136724 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_183339 (1) 2369bp
    Genomic GenBank:CR936518 (1) 218719bp Blast at MegaBLAST
    Polypeptide UniProtKB:B8JJ43 (1) 468aa
    Sequence Clusters UniGene:78157 (1)
    Sequence Information (all 23)
    OTHER tbx1 GENE PAGES
  • Gene:368206 (1)
  • VEGA:OTTDARG00000020120 (1)
  • VEGA:OTTDARG00000041627 (1)
  • Ensembl(GRCz10):ENSDARG00000031891 (1)
  • ORTHOLOGY for tbx1 (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human TBX1 22
  • Gene:6899
  • OMIM:602054
  • HGNC:11592
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Mouse Tbx1 16
  • MGI:98493
  • Gene:21380
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (69)