ZFIN ID: ZDB-GENE-030616-588
Gene Name: NEDD8 ubiquitin like modifier
Gene Symbol: nedd8    Nomenclature History

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Previous Name: si:zc14a17.5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have protein tag and ubiquitin protein ligase binding activity. Involved in defense response to virus. Predicted to localize to cytoplasm and nucleus. Is expressed in brain. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier).
Genome Resources: Alliance (1),  Gene:368667 (1),  Ensembl(GRCz11):ENSDARG00000007989 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66411]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb1227 Small Deletion Exon 3 Unknown CRISPR
sa40881 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nedd8 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nedd8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nedd8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to virus (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein tag (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nedd8-201 (1)    Ensembl 654
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nedd8 No data available
    MARKER RELATIONSHIPS
    nedd8 Contained in: [BAC] CH211-14A17 (1), CH211-216P19 (1)
    nedd8 Encodes: [cDNA] MGC:66411 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201321 (1) 658 nt
    Genomic GenBank:CR318603 (1) 188703 nt
    Select Tool
    Polypeptide UniProtKB:F1QMF9 (1) 89 aa
    Sequence Information (all 12)
    ORTHOLOGY for nedd8 ( Chr: 7 )
    CITATIONS (23)