ZFIN ID: ZDB-GENE-030616-450
Gene Name: erythrocyte membrane protein band 4.1 like 5
Gene Symbol: epb41l5    Nomenclature History

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Previous Names: moe, mosaic eyes, si:dz104f18.2, si:dz104f18.3, si:dz37o5.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have cytoskeletal protein binding activity. Involved in several processes, including animal organ development; maintenance of epithelial cell apical/basal polarity; and positive regulation of Notch signaling pathway. Localizes to bicellular tight junction and protein-containing complex. Is expressed in integument; nervous system; and pronephros. Used to study proteinuria. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5).
Genome Resources: Alliance (1),  Gene:368449 (1),  Ensembl(GRCz11):ENSDARG00000032324 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b476 Small Deletion Unknown Unknown G_RAYS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b781 Point Mutation Unknown Premature Stop ENU
    b882 Point Mutation Donor Splice Site of Exon 5 Intron Gain of Intron 5
    epb41l5_unspecified Unspecified Unknown Unknown
    la026880Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw170 Unknown Unknown Unknown
    rw306 Point Mutation Unknown Missense ENU
    rw310 Unknown Unknown Unknown
    sa2498 Point Mutation Unknown Premature Stop ENU
    sa7186 Point Mutation Unknown Premature Stop ENU
    sa9677 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27410 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34663 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-epb41l5 N/A 1
    MO2-epb41l5 N/A 1
    DISEASE ASSOCIATED WITH epb41l5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH epb41l5 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    proteinuria epb41l5b882/b882(TU) standard conditions Kramer-Zucker et al., 2005
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular protein-containing complex localization (more)
    Cellular Component protein-containing complex (more)
    Molecular Function cytoskeletal protein binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA epb41l5-002 (1) 2557
    epb41l5-202 (1)    Ensembl 4081
    epb41l5-203 (1)    Ensembl 2331
    epb41l5-204 (1)    Ensembl 1939
    ottdart00000001896 (1) 2476
    ottdart00000001898 (1) 1410
    ottdart00000001904 (1) 180
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-epb41l5 polyclonal Rabbit IHC, WB 2
    Ab2-epb41l5 polyclonal Guinea pig IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM epb41l5 No data available
    MARKER RELATIONSHIPS
    epb41l5 Contained in: [BAC] CH211-81J7 (1)
    [PAC] BUSM1-37O5 (1), BUSM1-104F18
    epb41l5 Encodes: [cDNA] MGC:77253 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200089 (1) 4104 nt
    Genomic GenBank:CR853293 (1) 151736 nt
    Select Tool
    Polypeptide UniProtKB:F6NJ58 (1) 783 aa
    Sequence Information (all 34)
    ORTHOLOGY for epb41l5 ( Chr: 9 )
    CITATIONS (45)