Gene

skp2

ID
ZDB-GENE-030219-158
Name
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Symbol
skp2 Nomenclature History
Previous Names
  • id:ibd5121
  • sb:cb933
  • wu:fa10b08
  • wu:fj97b11
  • zgc:162950
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and regulation of cell cycle. Predicted to localize to SCF ubiquitin ligase complex; cytosol; and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With skp2 Human Ortholog
No data available
Associated With skp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001810 F-box domain
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036047 F-box-like domain superfamily
Repeat IPR006553 Leucine-rich repeat, cysteine-containing subtype
Domain Details Per Protein
Protein Length F-box domain F-box-like domain superfamily Leucine-rich repeat, cysteine-containing subtype Leucine-rich repeat domain superfamily
UniProtKB:E9QCZ4 114
UniProtKB:F1QDJ7 264
UniProtKB:A3KP53 410
UniProtKB:E9QJ20 85
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations