ZFIN ID: ZDB-GENE-030131-9877
Gene Name: LLGL scribble cell polarity complex component 2
Gene Symbol: llgl2    Nomenclature History

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Previous Names: lgl2 (1), cb521 (1), pen, penner, sb:cb521, wu:fc06g08, wu:fl37c09, zgc:55895

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have GTPase activator activity; Rab GTPase binding activity; and myosin II binding activity. Involved in several processes, including Kupffer's vesicle development; hemidesmosome assembly; and motile cilium assembly. Predicted to localize to cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including EVL; Kupffer's vesicle; digestive system; mesoderm; and sensory system. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2).
Genome Resources: Alliance (1),  Gene:795670 (1),  Ensembl(GRCz11):ENSDARG00000023920 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012203Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018226Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31887 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38900 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • to6 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-llgl2 N/A 10
    MO2-llgl2 N/A 1
    MO3-llgl2 N/A 3
    DISEASE ASSOCIATED WITH llgl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH llgl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell projection assembly (more)
    Cellular Component cytoplasm (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA llgl2-201 (1)    Ensembl 4300
    llgl2-202 (1)    Ensembl 950
    ncRNA llgl2-002 (1)    Ensembl 503
    llgl2-003 (1)    Ensembl 610
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-llgl2 polyclonal IHC 8
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM llgl2 No data available
    MARKER RELATIONSHIPS
    llgl2 Contained in: [BAC] CH73-77C22 (1), DKEYP-67E6 (1)
    [Fosmid] CH1073-342O4 (1)
    llgl2 Encodes: [EST] cb521 (1) (order this), fc06g08 (1), fl37c09 (1), IMAGE:7154746 (1)
    [cDNA] MGC:55895 (1), MGC:198362 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212582 (1) 4287 nt
    Genomic GenBank:CR405682 (1) 192457 nt
    Select Tool
    Polypeptide UniProtKB:B7ZVM2 (1) 1020 aa
    Sequence Information (all 28)
    ORTHOLOGY for llgl2 ( Chr: 12 )
    CITATIONS (50)