ZFIN ID: ZDB-GENE-030131-9854
Gene Name: grainyhead-like transcription factor 3
Gene Symbol: grhl3    Nomenclature History

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Previous Names: cb467 (1), sb:cb467 (1), si:dkey-221l4.7, wu:fa01c12, wu:fb74c01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including chordate embryonic development; epiboly; and face morphogenesis. Predicted to localize to the nucleus. Is expressed in several structures, including EVL; margin; periderm; pharynx; and superficial blastomere. Orthologous to human GRHL3 (grainyhead like transcription factor 3).
Genome Resources: Alliance (1),  Gene:794613 (1),  Ensembl(GRCz11):ENSDARG00000078552 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ltu1 Indel Exon 4 Premature Stop CRISPR
sa17961 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grhl3 1
    MO1-grhl3 N/A 2
    MO2-grhl3 N/A 3
    MO3-grhl3 N/A 2
    DISEASE ASSOCIATED WITH grhl3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Van der Woude syndrome Alliance Van der Woude syndrome 2 606713
    DISEASE ASSOCIATED WITH grhl3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to xenobiotic stimulus (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR007604 CP2 transcription factor
    Family IPR040167 Transcription factor CP2-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grhl3-201 (1)    Ensembl 2659
    grhl3-203 (1)    Ensembl 776
    ncRNA grhl3-002 (1)    Ensembl 793
    grhl3-004 (1)    Ensembl 527
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grhl3 No data available
    MARKER RELATIONSHIPS
    grhl3 Contained in: [BAC] DKEY-221L4 (1) (order this)
    grhl3 Encodes: [EST] cb467 (1) (order this), fa01c12 (1), fb74c01 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005158558 (1)
    Genomic GenBank:AL928908 (1) 229790 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7F6C3 (1) 557 aa
    Sequence Information (all 29)
    ORTHOLOGY for grhl3 ( Chr: 17 )
    CITATIONS (33)