ZFIN ID: ZDB-GENE-030131-9814
Gene Name: R-spondin 3
Gene Symbol: rspo3    Nomenclature History

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Previous Names: cb387 (1), sb:cb387, wu:fa13e08, zgc:162040

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; and posterior lateral line neuromast development. Predicted to localize to the extracellular space. Is expressed in several structures, including digestive system; endoderm; forebrain neural keel; nervous system; and presumptive telencephalon. Orthologous to human RSPO3 (R-spondin 3).
Genome Resources: Alliance (1),  Gene:100007702 (1),  Ensembl(GRCz11):ENSDARG00000070081 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14295 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rspo3 N/A 1
    MO2-rspo3 N/A 1
    MO3-rspo3 N/A 1
    DISEASE ASSOCIATED WITH rspo3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rspo3 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
    Repeat IPR006212 Furin-like repeat
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Family IPR042994 R-spondin-3
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rspo3-201 (1)    Ensembl 2194
    ncRNA rspo3-002 (1) 629
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rspo3 No data available
    MARKER RELATIONSHIPS
    rspo3 Contained in: [BAC] CH211-195P4 (1), DKEY-242E21 (1) (order this)
    rspo3 Encodes: [EST] cb387 (1) (order this), fa13e08 (1)
    [cDNA] MGC:162040 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017358 (1) 2193 bp
    Genomic GenBank:BX470182 (1) 199742 bp
    Select Tool
    Polypeptide UniProtKB:F1R6D4 (1) 317 aa
    Sequence Information (all 27)
    ORTHOLOGY for rspo3 ( Chr: 16 )
    CITATIONS (31)